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Gene: Lck (lymphocyte protein tyrosine kinase) Mus musculus
Symbol: Lck
Name: lymphocyte protein tyrosine kinase
Description: Exhibits several functions, including CD4 receptor binding activity; protein antigen binding activity; and protein phosphatase binding activity. Involved in several processes, including positive regulation of macromolecule metabolic process; protein phosphorylation; and regulation of T cell differentiation. Localizes to cell-cell junction. Colocalizes with plasma membrane. Is expressed in several structures, including 2-cell stage embryo; nervous system; neural ectoderm; sensory organ; and thymus primordium. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human LCK (LCK proto-oncogene, Src family tyrosine kinase); PARTICIPATES IN eicosanoid signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; glypican signaling pathway; INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Hck-3; leukocyte C-terminal Src kinase; Lsk; Lskt; lymphocyte cell-specific protein-tyrosine kinase; p56-LCK; p56; p56Lck; proto-oncogene tyrosine-protein kinase LCK
Homo sapiens (human) : LCK (LCK proto-oncogene, Src family tyrosine kinase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Lck (LCK proto-oncogene, Src family tyrosine kinase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lck (LCK proto-oncogene, Src family tyrosine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : LCK (LCK proto-oncogene, Src family tyrosine kinase)
Canis lupus familiaris (dog) : LCK (LCK proto-oncogene, Src family tyrosine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lck (LCK proto-oncogene, Src family tyrosine kinase)
Sus scrofa (pig) : LCK (LCK proto-oncogene, Src family tyrosine kinase)
Chlorocebus sabaeus (African green monkey) : LCK (LCK proto-oncogene, Src family tyrosine kinase)
Heterocephalus glaber (naked mole-rat) : Lck (LCK proto-oncogene, Src family tyrosine kinase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl4129,548,344 - 129,573,641 (-)EnsemblGRCm38mm10GRCm38
GRCm384129,548,344 - 129,573,641 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv374129,225,588 - 129,250,885 (-)NCBIGRCm37mm9NCBIm37
MGSCv364129,050,662 - 129,060,676 (-)NCBImm8
Celera4127,881,707 - 127,907,449 (-)NCBICelera
Cytogenetic Map4D2.2NCBI
cM Map463.26NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Lck
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10861
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.