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Gene: Ldlr (low density lipoprotein receptor) Mus musculus
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Symbol: Ldlr
Name: low density lipoprotein receptor
Description: Exhibits amyloid-beta binding activity; lipoprotein particle receptor activity; and low-density lipoprotein particle binding activity. Involved in several processes, including lipid transport; regulation of inflammatory response; and regulation of lipid metabolic process. Localizes to several cellular components, including the basolateral plasma membrane; cell; and endosome. Used to study familial hypercholesterolemia and fatty liver disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; arteriosclerosis; familial hypercholesterolemia; hepatitis C; and migraine without aura. Is expressed in several structures, including alimentary system; genitourinary system; musculoskeletal system; paravertebral ganglion; and ventral grey horn. Orthologous to human LDLR (low density lipoprotein receptor); PARTICIPATES IN atherosclerosis pathway; bile acid transport pathway; endocytosis pathway; INTERACTS WITH (2R,4R)-1-[(2S)-5-(diaminomethylideneamino)-2-[(3-methyl-1,2,3,4-tetrahydroquinolin-8-yl)sulfonylamino]-1-oxopentyl]-4-methyl-2-piperidinecarboxylic acid; 2,3,7,8-tetrachlorodibenzodioxine; 2-butoxyethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Hlb301; LDL receptor; low-density lipoprotein receptor
Orthologs:
Homo sapiens (human) : LDLR (low density lipoprotein receptor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ldlr (low density lipoprotein receptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ldlr (low density lipoprotein receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : LDLR (low density lipoprotein receptor)
Canis lupus familiaris (dog) : LDLR (low density lipoprotein receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ldlr (low density lipoprotein receptor)
Sus scrofa (pig) : LDLR (low density lipoprotein receptor)
Chlorocebus sabaeus (African green monkey) : LDLR (low density lipoprotein receptor)
Heterocephalus glaber (naked mole-rat) : Ldlr (low density lipoprotein receptor)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl921,723,483 - 21,749,919 (+)Ensembl
GRCm38921,723,576 - 21,749,919 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37921,528,038 - 21,554,363 (+)NCBIGRCm37mm9NCBIm37
MGSCv36921,474,180 - 21,498,819 (+)NCBImm8
Celera918,993,169 - 19,019,513 (+)NCBICelera
Cytogenetic Map9A3NCBI
cM Map97.87NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model