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Gene: Mal (myelin and lymphocyte protein, T cell differentiation protein) Mus musculus
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Symbol: Mal
Name: myelin and lymphocyte protein, T cell differentiation protein
Description: Predicted to be a structural constituent of myelin sheath. Involved in several processes, including positive regulation of extrinsic apoptotic signaling pathway via death domain receptors; protein insertion into plasma membrane; and protein localization to paranode region of axon. Localizes to hinge region between urothelial plaques of apical plasma membrane and plasma membrane raft. Human ortholog(s) of this gene implicated in metachromatic leukodystrophy. Is expressed in lung; metanephros; and peripheral nervous system. Orthologous to human MAL (mal, T cell differentiation protein).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: MPV17; myelin and lymphocyte protein; myelin and lymphocyte protein, T-cell differentiation protein; T-lymphocyte maturation-associated protein; VIP17
Orthologs:
Homo sapiens (human) : MAL (mal, T cell differentiation protein)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Mal (mal, T-cell differentiation protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mal (mal, T cell differentiation protein)
Pan paniscus (bonobo/pygmy chimpanzee) : MAL (mal, T cell differentiation protein)
Canis lupus familiaris (dog) : MAL (mal, T cell differentiation protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101963404 (myelin and lymphocyte protein)
Sus scrofa (pig) : MAL (mal, T cell differentiation protein)
Chlorocebus sabaeus (African green monkey) : MAL (mal, T cell differentiation protein)
Heterocephalus glaber (naked mole-rat) : Mal (mal, T cell differentiation protein)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl2127,633,226 - 127,656,695 (-)EnsemblGRCm38mm10GRCm38
GRCm382127,633,226 - 127,656,695 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372127,458,962 - 127,482,431 (-)NCBIGRCm37mm9NCBIm37
MGSCv362127,324,671 - 127,347,724 (-)NCBImm8
Celera2128,878,634 - 128,902,174 (-)NCBICelera
Cytogenetic Map2F1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Mal
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10882
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.