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Gene: Met (met proto-oncogene) Mus musculus
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Symbol: Met
Name: met proto-oncogene
Description: Exhibits hepatocyte growth factor-activated receptor activity. Involved in several processes, including animal organ development; cell surface receptor signaling pathway; and positive regulation of MAPK cascade. Localizes to the membrane. Used to study Gilles de la Tourette syndrome; autism spectrum disorder; breast cancer; and gestational diabetes. Human ortholog(s) of this gene implicated in autistic disorder; autosomal recessive nonsyndromic deafness 97; carcinoma (multiple); and multiple myeloma. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and limb. Orthologous to human MET (MET proto-oncogene, receptor tyrosine kinase); PARTICIPATES IN altered scatter factor/hepatocyte growth factor signaling pathway; non-small cell lung carcinoma pathway; pancreatic cancer pathway; INTERACTS WITH 1,1-dichloroethene; 1,2-dimethylhydrazine; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI838057; c-Met; expressed sequence AI838057; hepatocyte growth factor receptor; HGF; HGF receptor; HGF/SF receptor; HGFR; met proto-oncogene tyrosine kinase; Par4; proto-oncogene c-Met; scatter factor receptor; SF receptor; tyrosine-protein kinase Met
Orthologs:
Homo sapiens (human) : MET (MET proto-oncogene, receptor tyrosine kinase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Met (MET proto-oncogene, receptor tyrosine kinase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Met (MET proto-oncogene, receptor tyrosine kinase)
Pan paniscus (bonobo/pygmy chimpanzee) : MET (MET proto-oncogene, receptor tyrosine kinase)
Canis lupus familiaris (dog) : MET (MET proto-oncogene, receptor tyrosine kinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Met (MET proto-oncogene, receptor tyrosine kinase)
Sus scrofa (pig) : MET (MET proto-oncogene, receptor tyrosine kinase)
Chlorocebus sabaeus (African green monkey) : MET (MET proto-oncogene, receptor tyrosine kinase)
Heterocephalus glaber (naked mole-rat) : Met (MET proto-oncogene, receptor tyrosine kinase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl617,463,800 - 17,573,980 (+)EnsemblGRCm38mm10GRCm38
GRCm38617,463,349 - 17,573,980 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37617,413,957 - 17,523,980 (+)NCBIGRCm37mm9NCBIm37
MGSCv36617,441,241 - 17,521,823 (+)NCBImm8
Celera617,538,386 - 17,649,457 (+)NCBICelera
Cytogenetic Map6A2NCBI
cM Map67.83NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Met
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10894
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.