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Gene: Msx2 (msh homeobox 2) Mus musculus
Symbol: Msx2
Name: msh homeobox 2
CRRD ID: 10921
Description: Exhibits DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and transcription factor binding activity. Involved in several processes, including animal organ development; embryonic limb morphogenesis; and regulation of gene expression. Localizes to transcription regulator complex. Is expressed in several structures, including alimentary system; embryo ectoderm; embryo mesenchyme; genitourinary system; and sensory organ. Used to study craniosynostosis and parietal foramina. Human ortholog(s) of this gene implicated in craniosynostosis and parietal foramina. Orthologous to human MSX2 (msh homeobox 2); INTERACTS WITH 17alpha-ethynylestradiol; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: BB122635; homeo box, msh-like 2; homeobox protein Hox-8-1; homeobox protein MSX-2; homeobox, msh-like 2; Hox; Hox-; Hox-8; Hox8; Hox8.; Hox8.1
Homo sapiens (human) : MSX2 (msh homeobox 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Msx2 (msh homeobox 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Msx2 (msh homeobox 2)
Pan paniscus (bonobo/pygmy chimpanzee) : MSX2 (msh homeobox 2)
Canis lupus familiaris (dog) : MSX2 (msh homeobox 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Msx2 (msh homeobox 2)
Sus scrofa (pig) : MSX2 (msh homeobox 2)
Chlorocebus sabaeus (African green monkey) : MSX2 (msh homeobox 2)
Heterocephalus glaber (naked mole-rat) : Msx2 (msh homeobox 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391353,620,917 - 53,626,816 (-)NCBI
GRCm381353,466,881 - 53,472,780 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1353,466,884 - 53,473,074 (-)EnsemblGRCm38mm10GRCm38
MGSCv371353,562,250 - 53,568,149 (-)NCBIGRCm37mm9NCBIm37
MGSCv361353,475,420 - 53,480,608 (-)NCBImm8
Celera1354,545,172 - 54,551,024 (-)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1327.84NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Msx2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10921
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-11-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.