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Gene: Myo5b (myosin VB) Mus musculus
Symbol: Myo5b
Name: myosin VB
Description: Predicted to have several functions, including Rab GTPase binding activity; actin filament binding activity; and ionotropic glutamate receptor binding activity. Involved in modulation of chemical synaptic transmission. Localizes to the Schaffer collateral - CA1 synapse and brush border. Predicted to colocalize with the recycling endosome. Used to study microvillus inclusion disease. Human ortholog(s) of this gene implicated in microvillus inclusion disease. Is expressed in central nervous system; genitourinary system; and gut. Orthologous to human MYO5B (myosin VB); PARTICIPATES IN insulin responsive facilitative sugar transporter mediated glucose transport pathway; vasopressin signaling pathway; vasopressin signaling pathway via receptor type 2; INTERACTS WITH (S)-nicotine; 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane; 17beta-estradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI661750; mKIAA1119; myosin-Vb; unconventional myosin-Vb
Homo sapiens (human) : MYO5B (myosin VB)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Myo5b (myosin Vb)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Myo5b (myosin VB)
Pan paniscus (bonobo/pygmy chimpanzee) : MYO5B (myosin VB)
Canis lupus familiaris (dog) : MYO5B (myosin VB)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Myo5b (myosin VB)
Sus scrofa (pig) : MYO5B (myosin VB)
Chlorocebus sabaeus (African green monkey) : MYO5B (myosin VB)
Heterocephalus glaber (naked mole-rat) : Myo5b (myosin VB)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1874,440,936 - 74,771,493 (+)EnsemblGRCm38mm10GRCm38
GRCm381874,442,364 - 74,772,698 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371874,602,273 - 74,931,131 (+)NCBIGRCm37mm9NCBIm37
MGSCv361874,567,984 - 74,896,170 (+)NCBImm8
Celera1875,677,935 - 75,995,786 (+)NCBICelera
Cytogenetic Map18E2NCBI
cM Map1850.7NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Myo5b
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10962
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.