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Gene: Nefh (neurofilament, heavy polypeptide) Mus musculus
Symbol: Nefh
Name: neurofilament, heavy polypeptide
Description: A structural constituent of postsynaptic intermediate filament cytoskeleton. Involved in cellular response to leukemia inhibitory factor; cytoskeleton organization; and peripheral nervous system neuron axonogenesis. Localizes to several cellular components, including Schaffer collateral - CA1 synapse; intermediate filament cytoskeleton; and postsynaptic density. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease axonal type 2CC; amyotrophic lateral sclerosis; amyotrophic lateral sclerosis type 1; and monoclonal gammopathy of uncertain significance. Orthologous to human NEFH (neurofilament heavy); PARTICIPATES IN amyotrophic lateral sclerosis pathway; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',5,5'-tetrachlorobiphenyl; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 200 kDa neurofilament protein; mKIAA0845; neurofilament 200kDa; neurofilament heavy polypeptide; neurofilament triplet H protein; NF-H; NF200; Nfh
Homo sapiens (human) : NEFH (neurofilament heavy)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Nefh (neurofilament heavy)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nefh (neurofilament heavy)
Pan paniscus (bonobo/pygmy chimpanzee) : NEFH (neurofilament heavy)
Canis lupus familiaris (dog) : NEFH (neurofilament heavy)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nefh (neurofilament heavy)
Sus scrofa (pig) : NEFH (neurofilament heavy)
Chlorocebus sabaeus (African green monkey) : NEFH (neurofilament heavy)
Heterocephalus glaber (naked mole-rat) : Nefh (neurofilament heavy)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl114,938,754 - 4,948,064 (-)EnsemblGRCm38mm10GRCm38
GRCm38114,938,754 - 4,948,064 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37114,838,757 - 4,848,067 (-)NCBIGRCm37mm9NCBIm37
MGSCv36114,838,761 - 4,851,268 (-)NCBImm8
Celera115,436,254 - 5,444,974 (-)NCBICelera
Cytogenetic Map11A1NCBI
cM Map113.12NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Nefh
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10969
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-06-19
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.