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Gene: Notch1 (notch 1) Mus musculus
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Symbol: Notch1
Name: notch 1
CRRD ID: 10998
Description: Exhibits several functions, including Notch binding activity; chromatin DNA binding activity; and molecular function regulator. Involved in several processes, including animal organ development; circulatory system development; and negative regulation of cell differentiation. Localizes to several cellular components, including adherens junction; apical plasma membrane; and cell surface. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome; adult T-cell leukemia; and aortic valve disease 1. Orthologous to human NOTCH1 (notch receptor 1); PARTICIPATES IN altered Notch signaling pathway involving the main players; Notch signaling pathway; Notch signaling pathway; INTERACTS WITH (+)-dexrazoxane; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 9930111A19Rik; lin; lin-12; major type A protein; Mi; Mis6; Motch A; mT14; N; N1; neurogenic locus notch homolog protein 1; Notch gene homolog 1; p300; Ta; Tan1; transmembrane receptor Notch1
Orthologs:
Homo sapiens (human) : NOTCH1 (notch receptor 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Notch1 (notch receptor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Notch1 (notch receptor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NOTCH1 (notch receptor 1)
Canis lupus familiaris (dog) : NOTCH1 (notch receptor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Notch1 (notch receptor 1)
Sus scrofa (pig) : NOTCH1 (notch receptor 1)
Chlorocebus sabaeus (African green monkey) : NOTCH1 (notch receptor 1)
Heterocephalus glaber (naked mole-rat) : Notch1 (notch receptor 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39226,347,914 - 26,393,834 (-)NCBI
GRCm38226,457,902 - 26,503,822 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl226,457,903 - 26,516,663 (-)EnsemblGRCm38mm10GRCm38
MGSCv37226,313,422 - 26,359,342 (-)NCBIGRCm37mm9NCBIm37
MGSCv36226,280,033 - 26,325,646 (-)NCBImm8
Celera226,175,736 - 26,221,759 (-)NCBICelera
Cytogenetic Map2A3NCBI
cM Map218.91NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Notch1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 10998
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-11-17
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.