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Gene: Npm1 (nucleophosmin 1) Mus musculus
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Symbol: Npm1
Name: nucleophosmin 1
Description: Exhibits identical protein binding activity; protein N-terminus binding activity; and rRNA binding activity. Involved in several processes, including positive regulation of macromolecule metabolic process; rRNA-containing ribonucleoprotein complex export from nucleus; and regulation of gene expression. Localizes to several cellular components, including centrosome; nuclear lumen; and ribosomal subunit. Used to study myelodysplastic syndrome. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Is expressed in several structures, including central nervous system; early conceptus; oocyte; and small intestine crypt of lieberkuhn. Orthologous to human NPM1 (nucleophosmin 1); PARTICIPATES IN hypoxia inducible factor pathway; INTERACTS WITH 1,2-dichloroethane; 17alpha-ethynylestradiol; 2,2',4,4'-Tetrabromodiphenyl ether.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: B23; MGC102162; MGC107291; NO38; Npm; nucleolar phosphoprotein B23; nucleolar protein NO38; nucleophosmin; numatrin
Orthologs:
Homo sapiens (human) : NPM1 (nucleophosmin 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Npm1 (nucleophosmin 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Npm1 (nucleophosmin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NPM1 (nucleophosmin 1)
Canis lupus familiaris (dog) : NPM1 (nucleophosmin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Npm1 (nucleophosmin 1)
Sus scrofa (pig) : NPM1 (nucleophosmin 1)
Chlorocebus sabaeus (African green monkey) : NPM1 (nucleophosmin 1)
Heterocephalus glaber (naked mole-rat) : Npm1 (nucleophosmin 1)
more info ...
Related Pseudogenes: Gm12583   Gm13423   Gm14776   Gm17060   Gm17895   Gm17898   Gm17905   Gm17906   Gm17910   Gm17911   Gm17917   Gm17921   Gm17922   Gm17925   Gm5611   Gm6477   Gm7289   Gm9118  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1133,152,287 - 33,163,206 (-)EnsemblGRCm38mm10GRCm38
GRCm381133,152,498 - 33,164,142 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371133,052,511 - 33,063,056 (-)NCBIGRCm37mm9NCBIm37
MGSCv361133,052,511 - 33,063,056 (-)NCBImm8
Celera1135,564,831 - 35,575,324 (-)NCBICelera
Cytogenetic Map11A4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Npm1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 11000
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.