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Gene: Npr3 (natriuretic peptide receptor 3) Mus musculus
Symbol: Npr3
Name: natriuretic peptide receptor 3
Description: Predicted to have several functions, including chloride ion binding activity; peptide receptor activity; and protein homodimerization activity. Involved in several processes, including negative regulation of cold-induced thermogenesis; osteoclast proliferation; and positive regulation of urine volume. Predicted to localize to membrane and protein-containing complex. Used to study bone disease. Human ortholog(s) of this gene implicated in hypertension. Is expressed in several structures, including cardiovascular system; central nervous system; lung; sensory organ; and urinary system. Orthologous to human NPR3 (natriuretic peptide receptor 3); PARTICIPATES IN C-type natriuretic peptide signaling pathway; INTERACTS WITH 1,1-dichloroethene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ANP-C; ANPR-C; atrial natriuretic peptide clearance receptor; atrial natriuretic peptide receptor 3; atrial natriuretic peptide receptor type C; B430320C24Rik; C81222; EF-2; lgj; longjohn; Nppc receptor; NPR-C; stri; strigosus
Homo sapiens (human) : NPR3 (natriuretic peptide receptor 3)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Npr3 (natriuretic peptide receptor 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Npr3 (natriuretic peptide receptor 3)
Pan paniscus (bonobo/pygmy chimpanzee) : NPR3 (natriuretic peptide receptor 3)
Canis lupus familiaris (dog) : NPR3 (natriuretic peptide receptor 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Npr3 (natriuretic peptide receptor 3)
Sus scrofa (pig) : NPR3 (natriuretic peptide receptor 3)
Chlorocebus sabaeus (African green monkey) : NPR3 (natriuretic peptide receptor 3)
Heterocephalus glaber (naked mole-rat) : Npr3 (natriuretic peptide receptor 3)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1511,839,896 - 11,907,287 (-)EnsemblGRCm38mm10GRCm38
GRCm381511,839,896 - 11,907,837 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371511,769,651 - 11,835,429 (-)NCBIGRCm37mm9NCBIm37
MGSCv361511,784,621 - 11,850,399 (-)NCBImm8
Celera1511,624,844 - 11,690,388 (-)NCBICelera
Cytogenetic Map15A1NCBI
cM Map155.83NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Npr3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 11008
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-05-19
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.