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Gene: Ntrk2 (neurotrophic tyrosine kinase, receptor, type 2) Mus musculus
Symbol: Ntrk2
Name: neurotrophic tyrosine kinase, receptor, type 2
CRRD ID: 11023
Description: Exhibits brain-derived neurotrophic factor binding activity and brain-derived neurotrophic factor-activated receptor activity. Involved in several processes, including modulation of chemical synaptic transmission; neurogenesis; and positive regulation of macromolecule metabolic process. Localizes to several cellular components, including early endosome; postsynaptic density; and postsynaptic membrane. Is expressed in several structures, including alimentary system; cardiovascular system; future brain; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in Alzheimer's disease; autistic disorder; early infantile epileptic encephalopathy 58; major depressive disorder; and morbid obesity. Orthologous to human NTRK2 (neurotrophic receptor tyrosine kinase 2); PARTICIPATES IN brain-derived neurotrophic factor signaling pathway; mitogen activated protein kinase signaling pathway; neurotrophic factor signaling pathway; INTERACTS WITH (+)-syringaresinol beta-D-glucoside; (20S)-ginsenoside Rg3; (S)-amphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI848316; BDNF/NT-3 growth factors receptor; C030027L06Rik; GP145-TrkB/GP95-TrkB; neurotrophic tyrosine kinase receptor type 2; neurotrophic tyrosine receptor kinase type 2; Tkr; Tkrb; trk; trk-B; trkB; trkB tyrosine kinase
Homo sapiens (human) : NTRK2 (neurotrophic receptor tyrosine kinase 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ntrk2 (neurotrophic receptor tyrosine kinase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ntrk2 (neurotrophic receptor tyrosine kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NTRK2 (neurotrophic receptor tyrosine kinase 2)
Canis lupus familiaris (dog) : NTRK2 (neurotrophic receptor tyrosine kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ntrk2 (neurotrophic receptor tyrosine kinase 2)
Sus scrofa (pig) : NTRK2 (neurotrophic receptor tyrosine kinase 2)
Chlorocebus sabaeus (African green monkey) : NTRK2 (neurotrophic receptor tyrosine kinase 2)
Heterocephalus glaber (naked mole-rat) : Ntrk2 (neurotrophic receptor tyrosine kinase 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391358,954,286 - 59,281,784 (+)NCBI
GRCm381358,806,472 - 59,133,970 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1358,806,569 - 59,133,970 (+)EnsemblGRCm38mm10GRCm38
MGSCv371358,907,957 - 59,231,337 (+)NCBIGRCm37mm9NCBIm37
MGSCv361358,816,219 - 59,139,599 (+)NCBImm8
Celera1359,869,829 - 60,184,466 (+)NCBICelera
Cytogenetic Map13B1NCBI
cM Map1331.2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Ntrk2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 11023
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-11-17
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.