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Gene: P4hb (prolyl 4-hydroxylase, beta polypeptide) Mus musculus
Symbol: P4hb
Name: prolyl 4-hydroxylase, beta polypeptide
Description: Exhibits integrin binding activity. Predicted to contribute to procollagen-proline 4-dioxygenase activity. Involved in cellular response to interleukin-7. Localizes to endoplasmic reticulum chaperone complex and external side of plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; cranium; heart; and sensory organ. Human ortholog(s) of this gene implicated in Cole-Carpenter syndrome. Orthologous to human P4HB (prolyl 4-hydroxylase subunit beta); PARTICIPATES IN Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH 1,2-dimethylhydrazine; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cellular thyroid hormone-binding protein; endoplasmic reticulum resident protein 59; ER protein 59; ERp59; p55; PDI; Pdia1; prolyl 4-hydroxylase subunit beta; protein disulfide isomerase; protein disulfide-isomerase; Thbp
Homo sapiens (human) : P4HB (prolyl 4-hydroxylase subunit beta)  HGNC  Alliance
Rattus norvegicus (Norway rat) : P4hb (prolyl 4-hydroxylase subunit beta)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : P4hb (prolyl 4-hydroxylase subunit beta)
Pan paniscus (bonobo/pygmy chimpanzee) : P4HB (prolyl 4-hydroxylase subunit beta)
Canis lupus familiaris (dog) : P4HB (prolyl 4-hydroxylase subunit beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : P4hb (prolyl 4-hydroxylase subunit beta)
Sus scrofa (pig) : P4HB (prolyl 4-hydroxylase subunit beta)
Chlorocebus sabaeus (African green monkey) : P4HB (prolyl 4-hydroxylase subunit beta)
Heterocephalus glaber (naked mole-rat) : P4hb (prolyl 4-hydroxylase subunit beta)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl11120,560,298 - 120,573,253 (-)EnsemblGRCm38mm10GRCm38
GRCm3811120,560,298 - 120,573,253 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3711120,421,618 - 120,434,250 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611120,376,394 - 120,389,026 (-)NCBImm8
Celera11132,295,664 - 132,308,296 (-)NCBICelera
Cytogenetic Map11E2NCBI
cM Map1184.27NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on P4hb
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 11046
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.