Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Pdgfa (platelet derived growth factor, alpha) Mus musculus
Symbol: Pdgfa
Name: platelet derived growth factor, alpha
Description: Predicted to have several functions, including platelet-derived growth factor binding activity; protein dimerization activity; and signaling receptor binding activity. Involved in several processes, including animal organ development; positive regulation of mesenchymal cell proliferation; and regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling. Localizes to extracellular space and microvillus. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in malignant glioma. Orthologous to human PDGFA (platelet derived growth factor subunit A); PARTICIPATES IN ceramide signaling pathway; platelet-derived growth factor signaling pathway; glioma pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: PDGF A-chain; PDGF subunit A; PDGF-1; platelet-derived growth factor A chain; platelet-derived growth factor A-chain; platelet-derived growth factor alpha polypeptide; platelet-derived growth factor subunit A
Homo sapiens (human) : PDGFA (platelet derived growth factor subunit A)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pdgfa (platelet derived growth factor subunit A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pdgfa (platelet derived growth factor subunit A)
Pan paniscus (bonobo/pygmy chimpanzee) : PDGFA (platelet derived growth factor subunit A)
Canis lupus familiaris (dog) : PDGFA (platelet derived growth factor subunit A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pdgfa (platelet derived growth factor subunit A)
Sus scrofa (pig) : PDGFA (platelet derived growth factor subunit A)
Chlorocebus sabaeus (African green monkey) : PDGFA (platelet derived growth factor subunit A)
Heterocephalus glaber (naked mole-rat) : Pdgfa (platelet derived growth factor subunit A)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl5138,976,014 - 138,997,370 (-)EnsemblGRCm38mm10GRCm38
GRCm385138,976,014 - 139,000,792 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375139,452,925 - 139,470,907 (-)NCBIGRCm37mm9NCBIm37
MGSCv365139,230,613 - 139,248,595 (-)NCBImm8
Celera5136,032,139 - 136,049,986 (-)NCBICelera
Cytogenetic Map5G2NCBI
cM Map577.65NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Pdgfa
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 11067
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.