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Gene: Abcb4 (ATP-binding cassette, sub-family B (MDR/TAP), member 4) Mus musculus
Symbol: Abcb4
Name: ATP-binding cassette, sub-family B (MDR/TAP), member 4
CRRD ID: 11094
Description: Predicted to have ATPase-coupled transmembrane transporter activity and phosphatidylcholine floppase activity. Involved in bile acid secretion and response to fenofibrate. Localizes to intercellular canaliculus and plasma membrane. Is expressed in alimentary system and liver. Used to study cholecystitis; cholestasis; hepatocellular carcinoma; intrahepatic cholestasis; and primary sclerosing cholangitis. Human ortholog(s) of this gene implicated in cholestasis (multiple); gallbladder disease; and liver cirrhosis (multiple). Orthologous to human ABCB4 (ATP binding cassette subfamily B member 4); PARTICIPATES IN multidrug resistance protein mediated transport pathway; bile acid transport pathway; INTERACTS WITH (2,4,5-trichlorophenoxy)acetic acid; (RS)-coclaurine; (RS)-norcoclaurine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ATP-binding cassette sub-family B member 4; Mdr; mdr-; mdr-2; Mdr2; multidrug resistance protein 2; multidrug resistance protein 3; P glycoprotein 2; P-glycoprotein 2; P-glycoprotein 3; Pgy; Pgy-; Pgy-2; Pgy2; phosphatidylcholine translocator ABCB4
Homo sapiens (human) : ABCB4 (ATP binding cassette subfamily B member 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Abcb4 (ATP binding cassette subfamily B member 4)  Alliance
Pan paniscus (bonobo/pygmy chimpanzee) : ABCB4 (ATP binding cassette subfamily B member 4)
Canis lupus familiaris (dog) : ABCB4 (ATP binding cassette subfamily B member 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Abcb4 (ATP binding cassette subfamily B member 4)
Sus scrofa (pig) : ABCB4 (ATP binding cassette subfamily B member 4)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm3958,943,614 - 9,009,226 (+)NCBI
GRCm3858,893,614 - 8,959,226 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl58,893,717 - 8,959,231 (+)EnsemblGRCm38mm10GRCm38
MGSCv3758,893,721 - 8,959,226 (+)NCBIGRCm37mm9NCBIm37
MGSCv3658,899,723 - 8,965,232 (+)NCBImm8
Celera58,813,446 - 8,878,635 (+)NCBICelera
Cytogenetic Map5A1NCBI
cM Map53.43NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Abcb4
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 11094
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-11-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.