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Gene: Phex (phosphate regulating endopeptidase homolog, X-linked) Mus musculus
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Symbol: Phex
Name: phosphate regulating endopeptidase homolog, X-linked
Description: Predicted to have metal ion binding activity and metalloendopeptidase activity. Involved in bone mineralization; odontogenesis; and organophosphate metabolic process. Localizes to Golgi apparatus; endoplasmic reticulum; and perinuclear region of cytoplasm. Used to study X-linked dominant hypophosphatemic rickets and otitis media. Human ortholog(s) of this gene implicated in X-linked dominant hypophosphatemic rickets. Is expressed in several structures, including chondrocranium; epidermis; limb; liver; and tooth. Orthologous to human PHEX (phosphate regulating endopeptidase homolog X-linked); INTERACTS WITH (2E,4E)-hexa-2,4-dienoic acid; 1,4-dioxane; 17beta-hydroxy-5alpha-androstan-3-one.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Gy; HPDR; HPDR1; Hyp; metalloendopeptidase homolog; metalloendopeptidase homolog PEX; Metalloendopeptidase homolog PEX (Phosphate regulating neutral endopeptidase) (X-linked hypophosphatemia protein) (HYP) (Vitamin D-resistant hypophosphatemic rickets protein); PEX; phosphate regulating gene with homologies to endopeptidases on the X chromosome (hypophosphatemia, vitamin D resistant rickets); phosphate regulating neutral endopeptidase; phosphate-regulating neutral endopeptidase PHEX; vitamin D-resistant hypophosphatemic rickets protein; X-linked hypophosphatemia protein; X-linked phosphate regulating endopeptidase
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 EnsemblX157,162,075 - 157,415,312 (-)EnsemblGRCm38mm10GRCm38
GRCm38X157,162,075 - 157,415,286 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37X153,596,618 - 153,853,218 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X152,502,794 - 152,759,383 (-)NCBImm8
CeleraX140,419,752 - 140,667,816 (-)NCBICelera
Cytogenetic MapXF4NCBI
cM MapX72.38NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Phex
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 11097
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.