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Gene: Pik3r1 (phosphoinositide-3-kinase regulatory subunit 1) Mus musculus
Symbol: Pik3r1
Name: phosphoinositide-3-kinase regulatory subunit 1
Description: Exhibits several functions, including insulin receptor substrate binding activity; phosphatidylinositol 3-kinase regulatory subunit binding activity; and protein heterodimerization activity. Predicted to contribute to 1-phosphatidylinositol-3-kinase activity. Involved in several processes, including apoptotic signaling pathway; negative regulation of osteoclast differentiation; and regulation of cellular protein localization. Localizes to several cellular components, including the cell-cell junction; cis-Golgi network; and perinuclear endoplasmic reticulum membrane. Used to study X-linked agammaglobulinemia. Human ortholog(s) of this gene implicated in several diseases, including astroblastoma; endometrial cancer (multiple); lung small cell carcinoma; primary immunodeficiency disease (multiple); and type 2 diabetes mellitus. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and integumental system. Orthologous to human PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1); PARTICIPATES IN E-cadherin signaling pathway; ephrin - ephrin receptor bidirectional signaling axis; epidermal growth factor/neuregulin signaling pathway; INTERACTS WITH 17beta-estradiol; 2,2',4,4',5,5'-hexachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AA414921; C530050K14; p50alpha; p55alpha; p85alpha; phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; phosphatidylinositol 3-kinase regulatory subunit alpha; phosphatidylinositol 3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); PI3-kinase regulatory subunit alpha; PI3-kinase subunit p85-alpha; PI3K; PI3K regulatory subunit alpha; ptdIns-3-kinase regulatory subunit alpha; ptdIns-3-kinase regulatory subunit p85-alpha
Homo sapiens (human) : PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pik3r1 (phosphoinositide-3-kinase regulatory subunit 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pik3r1 (phosphoinositide-3-kinase regulatory subunit 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1)
Canis lupus familiaris (dog) : PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pik3r1 (phosphoinositide-3-kinase regulatory subunit 1)
Sus scrofa (pig) : PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1)
Chlorocebus sabaeus (African green monkey) : PIK3R1 (phosphoinositide-3-kinase regulatory subunit 1)
Heterocephalus glaber (naked mole-rat) : Pik3r1 (phosphoinositide-3-kinase regulatory subunit 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl13101,680,563 - 101,768,217 (-)EnsemblGRCm38mm10GRCm38
GRCm3813101,680,761 - 101,768,217 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3713102,450,716 - 102,538,172 (-)NCBIGRCm37mm9NCBIm37
MGSCv3613102,781,018 - 102,792,904 (-)NCBImm8
Celera13105,285,857 - 105,373,612 (-)NCBICelera
Cytogenetic Map13D1NCBI
cM Map1353.92NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Pik3r1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 11103
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.