Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Pklr (pyruvate kinase liver and red blood cell) Mus musculus
Symbol: Pklr
Name: pyruvate kinase liver and red blood cell
Description: Exhibits pyruvate kinase activity. Involved in response to other organism. Localizes to cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study malaria and pyruvate kinase deficiency of red cells. Human ortholog(s) of this gene implicated in Gaucher's disease; congenital nonspherocytic hemolytic anemia; malaria; pyruvate kinase deficiency of red cells; and type 2 diabetes mellitus. Orthologous to human PKLR (pyruvate kinase L/R); PARTICIPATES IN Fanconi syndrome pathway; forkhead class A signaling pathway; glycogen storage disease type VII pathway; INTERACTS WITH 1,1-dichloroethene; 1,2-dichloroethane; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: L-PK; Pk-1; Pk1; pyruvate kinase isozymes L/R; pyruvate kinase isozymes R/L; pyruvate kinase PKLR; R-PK
Homo sapiens (human) : PKLR (pyruvate kinase L/R)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pklr (pyruvate kinase L/R)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pklr (pyruvate kinase L/R)
Pan paniscus (bonobo/pygmy chimpanzee) : PKLR (pyruvate kinase L/R)
Canis lupus familiaris (dog) : PKLR (pyruvate kinase L/R)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pklr (pyruvate kinase L/R)
Sus scrofa (pig) : PKLR (pyruvate kinase L/R)
Chlorocebus sabaeus (African green monkey) : PKLR (pyruvate kinase L/R)
Heterocephalus glaber (naked mole-rat) : Pklr (pyruvate kinase L/R)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl389,136,142 - 89,146,784 (+)EnsemblGRCm38mm10GRCm38
GRCm38389,136,122 - 89,146,815 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37388,940,064 - 88,950,516 (+)NCBIGRCm37mm9NCBIm37
MGSCv36389,222,069 - 89,231,560 (+)NCBImm8
Celera389,168,271 - 89,180,284 (+)NCBICelera
Cytogenetic Map3F1NCBI
cM Map339.01NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Pklr
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 11113
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.