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Gene: Pklr (pyruvate kinase liver and red blood cell) Mus musculus
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Symbol: Pklr
Name: pyruvate kinase liver and red blood cell
Description: Exhibits pyruvate kinase activity. Involved in response to other organism. Localizes to cytoplasm and plasma membrane. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study malaria and pyruvate kinase deficiency of red cells. Human ortholog(s) of this gene implicated in Gaucher's disease; congenital nonspherocytic hemolytic anemia; malaria; pyruvate kinase deficiency of red cells; and type 2 diabetes mellitus. Orthologous to human PKLR (pyruvate kinase L/R); PARTICIPATES IN Fanconi syndrome pathway; forkhead class A signaling pathway; glycogen storage disease type VII pathway; INTERACTS WITH 1,1-dichloroethene; 1,2-dichloroethane; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: L-PK; Pk-1; Pk1; pyruvate kinase isozymes L/R; pyruvate kinase isozymes R/L; pyruvate kinase PKLR; R-PK
Orthologs:
Homo sapiens (human) : PKLR (pyruvate kinase L/R)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pklr (pyruvate kinase L/R)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pklr (pyruvate kinase L/R)
Pan paniscus (bonobo/pygmy chimpanzee) : PKLR (pyruvate kinase L/R)
Canis lupus familiaris (dog) : PKLR (pyruvate kinase L/R)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pklr (pyruvate kinase L/R)
Sus scrofa (pig) : PKLR (pyruvate kinase L/R)
Chlorocebus sabaeus (African green monkey) : PKLR (pyruvate kinase L/R)
Heterocephalus glaber (naked mole-rat) : Pklr (pyruvate kinase L/R)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl389,136,142 - 89,146,784 (+)EnsemblGRCm38mm10GRCm38
GRCm38389,136,122 - 89,146,815 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37388,940,064 - 88,950,516 (+)NCBIGRCm37mm9NCBIm37
MGSCv36389,222,069 - 89,231,560 (+)NCBImm8
Celera389,168,271 - 89,180,284 (+)NCBICelera
Cytogenetic Map3F1NCBI
cM Map339.01NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Pklr
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 11113
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.