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Gene: Pou1f1 (POU domain, class 1, transcription factor 1) Mus musculus
Symbol: Pou1f1
Name: POU domain, class 1, transcription factor 1
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific; chromatin binding activity; and sequence-specific DNA binding activity. Involved in several processes, including positive regulation of cellular biosynthetic process; positive regulation of growth; and somatotropin secreting cell development. Localizes to the nucleus. Predicted to colocalize with the chromatin. Human ortholog(s) of this gene implicated in panhypopituitarism and pituitary gland disease. Is expressed in several structures, including eye; genitourinary system; pituitary gland; and trunk somite. Orthologous to human POU1F1 (POU class 1 homeobox 1); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; bis(2-chloroethyl) sulfide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: dw; dwarf; GHF-1; growth hormone factor 1; Hmp1; Pit-1; Pit1; Pit1-rs1; pituitary specific transcription factor 1, related sequence 1; pituitary-specific positive transcription factor 1; pituitary-specific positive transcription factor 1 variant w; POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1)
Homo sapiens (human) : POU1F1 (POU class 1 homeobox 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Pou1f1 (POU class 1 homeobox 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pou1f1 (POU class 1 homeobox 1)
Pan paniscus (bonobo/pygmy chimpanzee) : POU1F1 (POU class 1 homeobox 1)
Canis lupus familiaris (dog) : POU1F1 (POU class 1 homeobox 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pou1f1 (POU class 1 homeobox 1)
Sus scrofa (pig) : POU1F1 (POU class 1 homeobox 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1665,520,511 - 65,535,005 (+)Ensembl
GRCm381665,520,512 - 65,535,018 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371665,520,964 - 65,534,316 (+)NCBIGRCm37mm9NCBIm37
MGSCv361665,438,862 - 65,453,277 (+)NCBImm8
Celera1665,789,753 - 65,803,104 (+)NCBICelera
Cytogenetic Map16 C1.3NCBI
cM Map1637.25NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Pou1f1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 11129
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-12-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.