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Gene: Prlr (prolactin receptor) Mus musculus
Symbol: Prlr
Name: prolactin receptor
Description: Exhibits prolactin receptor activity. Involved in several processes, including gland development; positive regulation of cold-induced thermogenesis; and receptor signaling pathway via JAK-STAT. Predicted to localize to the external side of plasma membrane and receptor complex. Used to study familial medullary thyroid carcinoma. Human ortholog(s) of this gene implicated in hyperprolactinemia. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; hemolymphoid system gland; and limb segment. Orthologous to human PRLR (prolactin receptor); PARTICIPATES IN Jak-Stat signaling pathway; INTERACTS WITH 1,1-dichloroethene; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI987712; Pr-1; Pr-3; PRL-R; Prlr-rs1; prolactin receptor related sequence 1
Homo sapiens (human) : PRLR (prolactin receptor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Prlr (prolactin receptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prlr (prolactin receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : PRLR (prolactin receptor)
Canis lupus familiaris (dog) : PRLR (prolactin receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prlr (prolactin receptor)
Sus scrofa (pig) : PRLR (prolactin receptor)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm381510,177,238 - 10,349,190 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371510,106,993 - 10,266,775 (+)NCBIGRCm37mm9NCBIm37
MGSCv361510,122,380 - 10,274,111 (+)NCBImm8
Celera159,973,912 - 10,146,486 (+)NCBICelera
Cytogenetic Map15 A1NCBI
cM Map155.23NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Prlr
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 11157
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.