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Gene: Prnp (prion protein) Mus musculus
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Symbol: Prnp
Name: prion protein
Description: Exhibits several functions, including amyloid-beta binding activity; aspartic-type endopeptidase inhibitor activity; and cupric ion binding activity. Involved in several processes, including negative regulation of cytokine production; positive regulation of protein localization to membrane; and regulation of protein phosphorylation. Localizes to several cellular components, including the Golgi apparatus; cell surface; and membrane raft. Colocalizes with the dendrite. Used to study Creutzfeldt-Jakob disease; Gerstmann-Straussler-Scheinker syndrome; and fatal familial insomnia. Human ortholog(s) of this gene implicated in Creutzfeldt-Jakob disease; Gerstmann-Straussler-Scheinker syndrome; Huntington's disease-like 1; fatal familial insomnia; and kuru. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PRNP (prion protein); PARTICIPATES IN glypican signaling pathway; iron uptake pathway; prion disease pathway; INTERACTS WITH 1,2-dichloroethane; 17alpha-ethynylestradiol; 17beta-hydroxy-5alpha-androstan-3-one.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AA960666; AI325101; CD230; major prion protein; Prn-i; Prn-p; PrP; prP27-30; prP33-35C; PrP; PrPC; PrPSc; Sinc
Orthologs:
Homo sapiens (human) : PRNP (prion protein)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Prnp (prion protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prnp (prion protein)
Pan paniscus (bonobo/pygmy chimpanzee) : PRNP (prion protein)
Canis lupus familiaris (dog) : PRNP (prion protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prnp (prion protein)
Sus scrofa (pig) : PRNP (prion protein)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm382131,909,928 - 131,938,436 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372131,735,664 - 131,764,167 (+)NCBIGRCm37mm9NCBIm37
MGSCv362131,601,398 - 131,629,868 (+)NCBImm8
Celera2133,143,177 - 133,164,084 (+)NCBICelera
Cytogenetic Map2 F2NCBI
cM Map264.07NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Prnp
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 11160
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-11-13
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.