Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Prnp (prion protein) Mus musculus
Symbol: Prnp
Name: prion protein
CRRD ID: 11160
Description: Exhibits several functions, including amyloid-beta binding activity; aspartic-type endopeptidase inhibitor activity; and cupric ion binding activity. Involved in several processes, including negative regulation of macromolecule metabolic process; positive regulation of protein localization to membrane; and positive regulation of protein phosphorylation. Localizes to several cellular components, including Golgi apparatus; membrane raft; and terminal bouton. Colocalizes with dendrite. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Used to study Creutzfeldt-Jakob disease; Gerstmann-Straussler-Scheinker syndrome; and fatal familial insomnia. Human ortholog(s) of this gene implicated in Creutzfeldt-Jakob disease; Gerstmann-Straussler-Scheinker syndrome; Huntington's disease-like 1; fatal familial insomnia; and kuru. Orthologous to human PRNP (prion protein); PARTICIPATES IN glypican signaling pathway; iron uptake pathway; prion disease pathway; INTERACTS WITH 1,2-dichloroethane; 1,2-dimethylhydrazine; 17alpha-ethynylestradiol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AA960666; AI325101; CD230; major prion protein; P; Prn-i; Prn-p; PrP; prP27-30; prP33-35C; PrP; PrPC; PrPSc; S; Sinc
Homo sapiens (human) : PRNP (prion protein)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Prnp (prion protein)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Prnp (prion protein)
Pan paniscus (bonobo/pygmy chimpanzee) : PRNP (prion protein)
Canis lupus familiaris (dog) : PRNP (prion protein)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Prnp (prion protein)
Sus scrofa (pig) : PRNP (prion protein)
Chlorocebus sabaeus (African green monkey) : PRNP (prion protein)
Heterocephalus glaber (naked mole-rat) : Prnp (prion protein)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm392131,751,848 - 131,780,356 (+)NCBI
GRCm382131,909,928 - 131,938,436 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2131,909,928 - 131,938,429 (+)EnsemblGRCm38mm10GRCm38
MGSCv372131,735,664 - 131,764,167 (+)NCBIGRCm37mm9NCBIm37
MGSCv362131,601,398 - 131,629,868 (+)NCBImm8
Celera2133,143,177 - 133,164,079 (+)NCBICelera
Cytogenetic Map2F2NCBI
cM Map264.07NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Prnp
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 11160
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-11-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.