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Gene: Ptgis (prostaglandin I2 (prostacyclin) synthase) Mus musculus
Symbol: Ptgis
Name: prostaglandin I2 (prostacyclin) synthase
Description: Predicted to have heme binding activity and prostaglandin-I synthase activity. Involved in decidualization and embryo implantation. Localizes to cytoplasm and nucleus. Human ortholog(s) of this gene implicated in essential hypertension and hypertension. Is expressed in several structures, including alimentary system; brain; ear; early embryo; and genitourinary system. Orthologous to human PTGIS (prostaglandin I2 synthase); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; INTERACTS WITH 17beta-estradiol; 2,3',4,4',5-Pentachlorobiphenyl; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Cyp8; Cyp8a1; Pgis; prostacyclin synthase
Homo sapiens (human) : PTGIS (prostaglandin I2 synthase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ptgis (prostaglandin I2 synthase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptgis (prostaglandin I2 synthase)
Pan paniscus (bonobo/pygmy chimpanzee) : PTGIS (prostaglandin I2 synthase)
Canis lupus familiaris (dog) : PTGIS (prostaglandin I2 synthase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptgis (prostaglandin I2 synthase)
Sus scrofa (pig) : PTGIS (prostaglandin I2 synthase)
Chlorocebus sabaeus (African green monkey) : PTGIS (prostaglandin I2 synthase)
Heterocephalus glaber (naked mole-rat) : Ptgis (prostaglandin I2 synthase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl2167,191,805 - 167,240,604 (-)EnsemblGRCm38mm10GRCm38
GRCm382167,203,194 - 167,252,150 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372167,028,696 - 167,066,037 (-)NCBIGRCm37mm9NCBIm37
MGSCv362166,894,401 - 166,931,742 (-)NCBImm8
Celera2173,143,332 - 173,180,671 (-)NCBICelera
Cytogenetic Map2H3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Ptgis
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 11183
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-05-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.