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Gene: H2-M3 (histocompatibility 2, M region locus 3) Mus musculus
Symbol: H2-M3
Name: histocompatibility 2, M region locus 3
CRRD ID: 11205
Description: Exhibits peptide antigen binding activity. Involved in several processes, including antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent; positive regulation of leukocyte mediated cytotoxicity; and response to bacterium. Localizes to MHC class Ib protein complex and external side of plasma membrane. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system; liver; and lung. Human ortholog(s) of this gene implicated in asthma and hepatitis C. Orthologous to human HLA-E (major histocompatibility complex, class I, E); HLA-F (major histocompatibility complex, class I, F); and HLA-G (major histocompatibility complex, class I, G); PARTICIPATES IN allograft rejection pathway; antigen processing and presentation pathway; autoimmune thyroiditis pathway; INTERACTS WITH 1,2-dimethylhydrazine; 2,3,7,8-tetrachlorodibenzodioxine; benzo[a]pyrene.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: H-2M3; Hmt; M3a; MHC class I-b antigen M3; MuprM3; MuprM301; MuprM302; R4B; R4B2
Related Pseudogenes: Gm18808  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391737,581,094 - 37,585,376 (+)NCBI
GRCm381737,270,234 - 37,274,485 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1737,270,220 - 37,274,484 (+)EnsemblGRCm38mm10GRCm38
MGSCv371737,407,179 - 37,411,430 (+)NCBIGRCm37mm9NCBIm37
MGSCv361736,878,315 - 36,882,539 (+)NCBImm8
Celera1740,693,062 - 40,697,313 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1719.16NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on H2-M3
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 11205
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.