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Gene: Scn4a (sodium channel, voltage-gated, type IV, alpha) Mus musculus
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Symbol: Scn4a
Name: sodium channel, voltage-gated, type IV, alpha
Description: Exhibits voltage-gated sodium channel activity. Involved in sodium ion transport. Predicted to localize to axon and voltage-gated sodium channel complex. Is expressed in heart; heart ventricle; and testis. Used to study hyperkalemic periodic paralysis and hypokalemic periodic paralysis. Human ortholog(s) of this gene implicated in congenital myasthenic syndrome 16; hyperkalemic periodic paralysis; and paramyotonia congenita of Von Eulenburg. Orthologous to human SCN4A (sodium voltage-gated channel alpha subunit 4); INTERACTS WITH 4,4'-diaminodiphenylmethane; amiodarone; bis(2-ethylhexyl) phthalate.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: mH2; Nav1.4; SkM1; sodium channel alpha-subunit; sodium channel protein skeletal muscle subunit alpha; sodium channel protein type 4 subunit alpha; sodium channel protein type IV subunit alpha; sodium channel, voltage-gated, type IV, alpha polypeptide; voltage-gated sodium channel subunit alpha Nav1.4
Orthologs:
Homo sapiens (human) : SCN4A (sodium voltage-gated channel alpha subunit 4)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Scn4a (sodium voltage-gated channel alpha subunit 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Scn4a (sodium voltage-gated channel alpha subunit 4)
Pan paniscus (bonobo/pygmy chimpanzee) : SCN4A (sodium voltage-gated channel alpha subunit 4)
Canis lupus familiaris (dog) : SCN4A (sodium voltage-gated channel alpha subunit 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Scn4a (sodium voltage-gated channel alpha subunit 4)
Sus scrofa (pig) : SCN4A (sodium voltage-gated channel alpha subunit 4)
Chlorocebus sabaeus (African green monkey) : SCN4A (sodium voltage-gated channel alpha subunit 4)
Heterocephalus glaber (naked mole-rat) : Scn4a (sodium voltage-gated channel alpha subunit 4)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl11106,318,592 - 106,353,288 (-)EnsemblGRCm38mm10GRCm38
GRCm3811106,317,545 - 106,365,559 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3711106,179,907 - 106,210,704 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611106,135,394 - 106,165,480 (-)NCBImm8
Celera11118,049,260 - 118,080,125 (-)NCBICelera
Cytogenetic Map11E1NCBI
cM Map1168.91NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
 
More on Scn4a
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 11268
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.