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Gene: Slc12a1 (solute carrier family 12, member 1) Mus musculus
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Symbol: Slc12a1
Name: solute carrier family 12, member 1
Description: Exhibits sodium:potassium:chloride symporter activity. Involved in several processes, including cellular hyperosmotic salinity response; excretion; and positive regulation of calcineurin-NFAT signaling cascade. Localizes to the apical plasma membrane. Used to study Bartter disease type 1. Human ortholog(s) of this gene implicated in Bartter disease and Bartter disease type 1. Is expressed in several structures, including alimentary system and urinary system. Orthologous to human SLC12A1 (solute carrier family 12 member 1); PARTICIPATES IN amiloride pharmacodynamics pathway; bendroflumethiazide pharmacodynamics pathway; bumetanide pharmacodynamics pathway; INTERACTS WITH 1,1-dichloroethene; 2,3,7,8-tetrachlorodibenzodioxine; ciguatoxin CTX1B.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI788571; BSC1; bumetanide-sensitive cotransporter type 1; bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2; D630042G03Rik; kidney-specific Na-K-Cl symporter; mBSC1; Nkcc2; solute carrier family 12 member 1; urehr3
Orthologs:
Homo sapiens (human) : SLC12A1 (solute carrier family 12 member 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Slc12a1 (solute carrier family 12 member 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc12a1 (solute carrier family 12 member 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC12A1 (solute carrier family 12 member 1)
Canis lupus familiaris (dog) : SLC12A1 (solute carrier family 12 member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc12a1 (solute carrier family 12 member 1)
Sus scrofa (pig) : SLC12A1 (solute carrier family 12 member 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm382125,152,510 - 125,230,002 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372124,978,336 - 125,055,738 (+)NCBIGRCm37mm9NCBIm37
MGSCv362124,844,041 - 124,921,440 (+)NCBImm8
Celera2126,402,848 - 126,480,313 (+)NCBICelera
Cytogenetic Map2 F1NCBI
cM Map261.23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Slc12a1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 11297
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.