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Gene: Sp4 (trans-acting transcription factor 4) Mus musculus
Symbol: Sp4
Name: trans-acting transcription factor 4
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in regulation of heart contraction. Predicted to localize to the cytosol and nucleoplasm. Used to study schizophrenia. Human ortholog(s) of this gene implicated in congenital heart disease and dilated cardiomyopathy. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; nervous system; and sensory organ. Orthologous to human SP4 (Sp4 transcription factor); INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2-butoxyethanol.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5730497N03Rik; HF-1b; HF1-b; transcription factor Sp4
Homo sapiens (human) : SP4 (Sp4 transcription factor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Sp4 (Sp4 transcription factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sp4 (Sp4 transcription factor)
Pan paniscus (bonobo/pygmy chimpanzee) : SP4 (Sp4 transcription factor)
Canis lupus familiaris (dog) : SP4 (Sp4 transcription factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sp4 (Sp4 transcription factor)
Sus scrofa (pig) : SP4 (Sp4 transcription factor)
Chlorocebus sabaeus (green monkey) : SP4 (Sp4 transcription factor)
Heterocephalus glaber (naked mole-rat) : Sp4 (Sp4 transcription factor)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl12118,234,933 - 118,301,440 (-)Ensembl
GRCm3812118,231,686 - 118,301,440 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3712119,473,406 - 119,539,913 (-)NCBIGRCm37mm9NCBIm37
MGSCv3612112,460,830 - 112,527,871 (-)NCBImm8
MGSCv3612118,679,035 - 118,745,471 (-)NCBImm8
Cytogenetic Map12 F2NCBI
cM Map1263.48NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Sp4
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 11335
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.