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Gene: Tap2 (transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)) Mus musculus
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Symbol: Tap2
Name: transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
CRRD ID: 11388
Description: Exhibits TAP1 binding activity. Predicted to contribute to MHC class I protein binding activity; peptide antigen binding activity; and peptide transmembrane transporter activity. Involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; and antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent. Predicted to localize to TAP complex and nuclear speck. Is expressed in hemolymphoid system and thymus primordium. Human ortholog(s) of this gene implicated in several diseases, including MHC class I deficiency; autoimmune disease (multiple); cervical cancer (multiple); dengue hemorrhagic fever; and systemic scleroderma (multiple). Orthologous to human TAP2 (transporter 2, ATP binding cassette subfamily B member).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ABC18; Abcb; Abcb3; AI462429; antigen peptide transporter 2; APT2; ATP dependent transport protein family member; ATP-binding cassette sub-family B member 3; ATP-binding cassette, sub-family B (MDR/TAP), member 3; Ham; Ham-; Ham-2; Ham2; histocompatibility antigen modifier 2; jas; MTP; MTP2; PS; PSF2; RING11; Tap; Tap-2; transporter 2 ATP-binding cassette sub-family B; transporter 2, ABC (ATP binding cassette); Y1
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391734,423,453 - 34,435,295 (+)NCBI
GRCm381734,204,479 - 34,216,321 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,203,527 - 34,216,321 (+)EnsemblGRCm38mm10GRCm38
MGSCv371734,341,424 - 34,353,266 (+)NCBIGRCm37mm9NCBIm37
MGSCv361733,814,778 - 33,826,596 (+)NCBImm8
Celera1736,957,240 - 36,969,164 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.98NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Tap2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 11388
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-11-10
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.