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Gene: Tap2 (transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)) Mus musculus
Symbol: Tap2
Name: transporter 2, ATP-binding cassette, sub-family B (MDR/TAP)
CRRD ID: 11388
Description: Exhibits TAP1 binding activity. Predicted to contribute to MHC class I protein binding activity; peptide antigen binding activity; and peptide transmembrane transporter activity. Involved in several processes, including antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent; antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent; and antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent. Predicted to localize to TAP complex and nuclear speck. Is expressed in hemolymphoid system and thymus primordium. Human ortholog(s) of this gene implicated in several diseases, including MHC class I deficiency; autoimmune disease (multiple); cervical cancer (multiple); dengue hemorrhagic fever; and systemic scleroderma (multiple). Orthologous to human TAP2 (transporter 2, ATP binding cassette subfamily B member).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ABC18; Abcb; Abcb3; AI462429; antigen peptide transporter 2; APT2; ATP dependent transport protein family member; ATP-binding cassette sub-family B member 3; ATP-binding cassette, sub-family B (MDR/TAP), member 3; Ham; Ham-; Ham-2; Ham2; histocompatibility antigen modifier 2; jas; MTP; MTP2; PS; PSF2; RING11; Tap; Tap-2; transporter 2 ATP-binding cassette sub-family B; transporter 2, ABC (ATP binding cassette); Y1
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm391734,423,453 - 34,435,295 (+)NCBI
GRCm381734,204,479 - 34,216,321 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1734,203,527 - 34,216,321 (+)EnsemblGRCm38mm10GRCm38
MGSCv371734,341,424 - 34,353,266 (+)NCBIGRCm37mm9NCBIm37
MGSCv361733,814,778 - 33,826,596 (+)NCBImm8
Celera1736,957,240 - 36,969,164 (+)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1717.98NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Tap2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 11388
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-11-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.