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Gene: Hnf1a (HNF1 homeobox A) Mus musculus
Symbol: Hnf1a
Name: HNF1 homeobox A
Description: Exhibits several functions, including DNA-binding transcription factor activity; identical protein binding activity; and protein dimerization activity. Involved in several processes, including animal organ development; glucose transmembrane transport; and lipid transport. Localizes to several cellular components, including photoreceptor outer segment; pronucleus; and transcription regulator complex. Is expressed in several structures, including extraembryonic component; genitourinary system; gut; septum transversum hepatic component; and spleen. Used to study maturity-onset diabetes of the young type 3; phenylketonuria; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in glucose metabolism disease (multiple); liver disease (multiple); and renal cell carcinoma. Orthologous to human HNF1A (HNF1 homeobox A).
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI323641; hepatocyte nuclear factor 1; hepatocyte nuclear factor 1-alpha; Hnf-1; HNF-1-alpha; HNF-1A; HNF1; HNF1-alpha; HNF1[a]; Hnf1alpha; LFB1; liver-specific transcription factor LF-B1; Tcf-1; Tcf1; transcription factor 1
Homo sapiens (human) : HNF1A (HNF1 homeobox A)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hnf1a (HNF1 homeobox A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hnf1a (HNF1 homeobox A)
Pan paniscus (bonobo/pygmy chimpanzee) : HNF1A (HNF1 homeobox A)
Canis lupus familiaris (dog) : HNF1A (HNF1 homeobox A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hnf1a (HNF1 homeobox A)
Sus scrofa (pig) : HNF1A (HNF1 homeobox A)
Chlorocebus sabaeus (African green monkey) : HNF1A (HNF1 homeobox A)
Heterocephalus glaber (naked mole-rat) : Hnf1a (HNF1 homeobox A)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl5114,948,980 - 114,971,094 (-)EnsemblGRCm38mm10GRCm38
GRCm385114,948,980 - 114,971,062 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv375115,398,989 - 115,421,071 (-)NCBIGRCm37mm9NCBIm37
MGSCv365115,209,360 - 115,232,037 (-)NCBImm8
Celera5112,043,825 - 112,067,328 (-)NCBICelera
Cytogenetic Map5FNCBI
cM Map555.99NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Hnf1a
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 11397
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-07-07
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.