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Gene: Hnf1b (HNF1 homeobox B) Mus musculus
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Symbol: Hnf1b
Name: HNF1 homeobox B
Description: Exhibits DNA-binding transcription factor activity, RNA polymerase II-specific; cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in several processes, including regulation of kidney development; regulation of transcription by RNA polymerase II; and tube morphogenesis. Localizes to nucleus and transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in kidney disease; maturity-onset diabetes of the young type 5; pancreas disease; renal cell carcinoma; and type 2 diabetes mellitus. Orthologous to human HNF1B (HNF1 homeobox B); PARTICIPATES IN forkhead class A signaling pathway; maturity-onset diabetes of the young pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI385728; AI987804; hepatocyte nuclear factor 1-beta; hepatocyte nuclear factor-1 beta; HNF-1-beta; HNF-1B; HNF-1Beta; Hnf1beta; homeoprotein LFB3; LFB3; Tcf-2; Tcf2; transcription factor 2; vHNF1
Orthologs:
Homo sapiens (human) : HNF1B (HNF1 homeobox B)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hnf1b (HNF1 homeobox B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hnf1b (HNF1 homeobox B)
Pan paniscus (bonobo/pygmy chimpanzee) : HNF1B (HNF1 homeobox B)
Canis lupus familiaris (dog) : HNF1B (HNF1 homeobox B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hnf1b (HNF1 homeobox B)
Sus scrofa (pig) : HNF1B (HNF1 homeobox B)
Chlorocebus sabaeus (African green monkey) : HNF1B (HNF1 homeobox B)
Heterocephalus glaber (naked mole-rat) : Hnf1b (HNF1 homeobox B)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38.p6 Ensembl1183,850,063 - 83,905,819 (+)EnsemblGRCm38mm10GRCm38
GRCm381183,850,209 - 83,905,917 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371183,664,371 - 83,719,317 (+)NCBIGRCm37mm9NCBIm37
MGSCv361183,667,244 - 83,721,542 (+)NCBImm8
Celera1193,455,173 - 93,510,691 (+)NCBICelera
Cytogenetic Map11CNCBI
cM Map1151.23NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Hnf1b
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 11398
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.