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Gene: Hnf1b (HNF1 homeobox B) Mus musculus
Symbol: Hnf1b
Name: HNF1 homeobox B
Description: Exhibits DNA-binding transcription factor activity, RNA polymerase II-specific; cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in several processes, including regulation of kidney development; regulation of transcription by RNA polymerase II; and tube morphogenesis. Localizes to nucleus and transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in kidney disease; maturity-onset diabetes of the young type 5; pancreas disease; renal cell carcinoma; and type 2 diabetes mellitus. Orthologous to human HNF1B (HNF1 homeobox B); PARTICIPATES IN forkhead class A signaling pathway; maturity-onset diabetes of the young pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI385728; AI987804; hepatocyte nuclear factor 1-beta; hepatocyte nuclear factor-1 beta; HNF-1-beta; HNF-1B; HNF-1Beta; Hnf1beta; homeoprotein LFB3; LFB3; Tcf-2; Tcf2; transcription factor 2; vHNF1
Homo sapiens (human) : HNF1B (HNF1 homeobox B)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Hnf1b (HNF1 homeobox B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hnf1b (HNF1 homeobox B)
Pan paniscus (bonobo/pygmy chimpanzee) : HNF1B (HNF1 homeobox B)
Canis lupus familiaris (dog) : HNF1B (HNF1 homeobox B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hnf1b (HNF1 homeobox B)
Sus scrofa (pig) : HNF1B (HNF1 homeobox B)
Chlorocebus sabaeus (African green monkey) : HNF1B (HNF1 homeobox B)
Heterocephalus glaber (naked mole-rat) : Hnf1b (HNF1 homeobox B)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1183,850,063 - 83,905,819 (+)EnsemblGRCm38mm10GRCm38
GRCm381183,850,209 - 83,905,917 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371183,664,371 - 83,719,317 (+)NCBIGRCm37mm9NCBIm37
MGSCv361183,667,244 - 83,721,542 (+)NCBImm8
Celera1193,455,173 - 93,510,691 (+)NCBICelera
Cytogenetic Map11CNCBI
cM Map1151.23NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Hnf1b
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 11398
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.