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Gene: Th (tyrosine hydroxylase) Mus musculus
Symbol: Th
Name: tyrosine hydroxylase
CRRD ID: 11414
Description: Predicted to have several functions, including cation binding activity; tetrahydrobiopterin binding activity; and tyrosine 3-monooxygenase activity. Involved in several processes, including dopamine biosynthetic process from tyrosine; eye development; and learning or memory. Localizes to several cellular components, including axon; perikaryon; and perinuclear region of cytoplasm. Is expressed in several structures, including alimentary system; cardiovascular system; eye; genitourinary system; and nervous system. Human ortholog(s) of this gene implicated in Parkinson's disease; hypertension; and obesity. Orthologous to human TH (tyrosine hydroxylase); PARTICIPATES IN aromatic L-amino acid decarboxylase deficiency pathway; catecholamine biosynthetic pathway; dopamine biosynthetic pathway; INTERACTS WITH (R)-adrenaline; (R)-mevalonic acid; (R)-noradrenaline.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: tyrosine 3-hydroxylase; tyrosine 3-monooxygenase
Homo sapiens (human) : TH (tyrosine hydroxylase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Th (tyrosine hydroxylase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Th (tyrosine hydroxylase)
Pan paniscus (bonobo/pygmy chimpanzee) : TH (tyrosine hydroxylase)
Canis lupus familiaris (dog) : TH (tyrosine hydroxylase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Th (tyrosine hydroxylase)
Sus scrofa (pig) : TH (tyrosine hydroxylase)
Chlorocebus sabaeus (African green monkey) : TH (tyrosine hydroxylase)
Heterocephalus glaber (naked mole-rat) : Th (tyrosine hydroxylase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm397142,446,516 - 142,453,732 (-)NCBI
GRCm387142,892,779 - 142,899,995 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7142,892,752 - 142,931,128 (-)EnsemblGRCm38mm10GRCm38
MGSCv377150,078,681 - 150,085,871 (-)NCBIGRCm37mm9NCBIm37
MGSCv367142,702,166 - 142,709,356 (-)NCBImm8
Celera7142,648,392 - 142,655,582 (-)NCBICelera
Cytogenetic Map7F5NCBI
cM Map788.06NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Th
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 11414
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-11-03
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.