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Gene: Nkx2-1 (NK2 homeobox 1) Mus musculus
Symbol: Nkx2-1
Name: NK2 homeobox 1
CRRD ID: 11420
Description: Exhibits DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and intronic transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; neurogenesis; and regulation of transcription by RNA polymerase II. Localizes to nucleus and transcription regulator complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in choreatic disease and thyroid gland papillary carcinoma. Orthologous to human NKX2-1 (NK2 homeobox 1); PARTICIPATES IN forkhead class A signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-sulfonyldiphenol; bisphenol A.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AV026640; homeobox protein Nkx-2.1; Nkx2.1; T/EB; T/EBP; thyroid nuclear factor 1; thyroid transcription factor 1; thyroid-specific enhancer-binding protein; ti; tinman; Titf; Titf1; Ttf-1
Homo sapiens (human) : NKX2-1 (NK2 homeobox 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Nkx2-1 (NK2 homeobox 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nkx2-1 (NK2 homeobox 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nkx2-1 (NK2 homeobox 1)
Sus scrofa (pig) : NKX2-1 (NK2 homeobox 1)
Chlorocebus sabaeus (African green monkey) : NKX2-1 (NK2 homeobox 1)
Heterocephalus glaber (naked mole-rat) : Nkx2-1 (NK2 homeobox 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
NCBI Annotation Information: Note: Ttf1 (GeneID 22130) and Nkx2-1 (GeneID 21869) loci share the Ttf1 symbol/alias in common. Ttf1 is a widely used alternative name for thyroid transcription factor 1 (Nkx2-1) conflicting with the official symbol for transcription termination factor, RNA polymerase I (Ttf1). [13 Feb 2013]
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1256,531,958 - 56,536,908 (-)EnsemblGRCm38mm10GRCm38
GRCm381256,531,935 - 56,536,908 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371257,632,922 - 57,637,895 (-)NCBIGRCm37mm9NCBIm37
MGSCv361257,449,970 - 57,454,920 (-)NCBImm8
Celera1257,681,286 - 57,686,296 (-)NCBICelera
Cytogenetic Map12C1NCBI
cM Map1224.42NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Nkx2-1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 11420
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-09-29
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.