Symbol:
Tle4
Name:
transducin-like enhancer of split 4
Description:
Exhibits several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; repressing transcription factor binding activity; and transcription corepressor activity. Involved in Wnt signaling pathway; cellular response to leukemia inhibitory factor; and negative regulation of transcription by RNA polymerase II. Localizes to the nucleus. Is expressed in several structures, including central nervous system; genitourinary system; peripheral nervous system ganglion; sensory organ; and trunk mesenchyme. Orthologous to human TLE4 (TLE family member 4, transcriptional corepressor); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxyphenyl retinamide; 5-aza-2'-deoxycytidine.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
5730411M05Rik; AA792082; B lymphocyte gene 1; Bce-1; Bce1; ESTM13; ESTM14; grg-4; Grg4; groucho-related protein 4; transducin-like enhancer of split 4, homolog of Drosophila E(spl); transducin-like enhancer protein 4; X83332; X83333
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Homo sapiens (human):
TLE4 (TLE family member 4, transcriptional corepressor) HGNC
EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, PhylomeDB, Treefam
Rattus norvegicus (Norway rat):
Tle4 (TLE family member 4, transcriptional corepressor) HGNC
Treefam, OrthoMCL, NCBI, OMA, HomoloGene, Inparanoid, Panther, OrthoDB, Ensembl
Chinchilla lanigera (long-tailed chinchilla):
Tle4 (TLE family member 4, transcriptional corepressor) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Canis lupus familiaris (dog):
TLE4 (TLE family member 4, transcriptional corepressor) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
Tle4 (TLE family member 4, transcriptional corepressor) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Sus scrofa (pig):
TLE4 (TLE family member 4, transcriptional corepressor) Transitive Ortholog Pipeline
Transitive Ortholog Pipeline
Other homologs 2
Homo sapiens (human):
TLE2 (TLE family member 2, transcriptional corepressor) HGNC
OrthoMCL
Homo sapiens (human):
TLE1 (TLE family member 1, transcriptional corepressor) HGNC
OrthoMCL
Homo sapiens (human):
TLE3 (TLE family member 3, transcriptional corepressor) HGNC
OrthoMCL
Homo sapiens (human):
TLE5 (TLE family member 5, transcriptional modulator) HGNC
Panther
Alliance orthologs 3
Rattus norvegicus (Norway rat):
Tle4 (TLE family member 4, transcriptional corepressor)
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OMA, OrthoFinder, PANTHER, PhylomeDB)
Homo sapiens (human):
TLE4 (TLE family member 4, transcriptional corepressor)
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Drosophila melanogaster (fruit fly):
gro
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Caenorhabditis elegans (roundworm):
unc-37
Alliance
DIOPT (Ensembl Compara, Hieranoid, InParanoid, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup)
Latest Assembly:
GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCm38 19 14,448,072 - 14,598,183 (-) NCBI GRCm38 GRCm38 mm10 GRCm38 MGSCv37 19 14,522,562 - 14,672,473 (-) NCBI GRCm37 mm9 NCBIm37 MGSCv36 19 14,515,091 - 14,665,002 (-) NCBI mm8 Celera 19 15,104,678 - 15,255,003 (-) NCBI Celera Cytogenetic Map 19 A NCBI cM Map 19 9.11 NCBI
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Disease Annotations
(-)-epigallocatechin 3-gallate multiple interactions ISO RGD:733230 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TLE4 mRNA CTD PMID:22079256 17beta-estradiol affects expression ISO RGD:733230 6480464 Estradiol affects the expression of TLE4 mRNA CTD PMID:22574217 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of TLE4 mRNA CTD PMID:19465110 2-ethoxyethanol increases expression ISO RGD:3868 6480464 2-ethoxyethanol results in increased expression of TLE4 mRNA CTD PMID:19643169 2-methoxyethanol increases expression ISO RGD:3868 6480464 methyl cellosolve results in increased expression of TLE4 mRNA CTD PMID:19643169 4-hydroxyphenyl retinamide increases expression EXP 6480464 Fenretinide results in increased expression of TLE4 mRNA CTD PMID:28973697 5-aza-2'-deoxycytidine increases expression EXP 6480464 Decitabine results in increased expression of TLE4 mRNA CTD PMID:27915011 6-propyl-2-thiouracil increases expression ISO RGD:3868 6480464 Propylthiouracil results in increased expression of TLE4 mRNA CTD PMID:24780913 7,12-dimethyltetraphene increases expression ISO RGD:3868 6480464 9 more ... CTD PMID:12376462 aflatoxin B1 affects expression ISO RGD:733230 6480464 Aflatoxin B1 affects the expression of TLE4 protein CTD PMID:20106945 aflatoxin B1 increases methylation ISO RGD:733230 6480464 Aflatoxin B1 results in increased methylation of TLE4 intron CTD PMID:30157460 all-trans-retinoic acid decreases expression ISO RGD:733230 6480464 Tretinoin results in decreased expression of TLE4 mRNA CTD PMID:21934132 ammonium chloride affects expression ISO RGD:3868 6480464 Ammonium Chloride affects the expression of TLE4 mRNA CTD PMID:16483693 antirheumatic drug decreases expression ISO RGD:733230 6480464 Antirheumatic Agents results in decreased expression of TLE4 mRNA CTD PMID:24449571 atrazine decreases expression ISO RGD:733230 6480464 Atrazine results in decreased expression of TLE4 mRNA CTD PMID:22378314 benzo[a]pyrene increases expression EXP 6480464 Benzo(a)pyrene results in increased expression of TLE4 mRNA CTD PMID:22228805 benzo[a]pyrene diol epoxide I decreases expression ISO RGD:733230 6480464 7 more ... CTD PMID:19150397 bisphenol A decreases expression ISO RGD:3868 6480464 bisphenol A results in decreased expression of TLE4 mRNA CTD PMID:25181051 bisphenol A increases methylation ISO RGD:3868 6480464 bisphenol A results in increased methylation of TLE4 gene CTD PMID:28505145 chromium(6+) affects expression ISO RGD:733230 6480464 chromium hexavalent ion affects the expression of TLE4 mRNA CTD PMID:30690063 cisplatin decreases expression ISO RGD:733230 6480464 Cisplatin results in decreased expression of TLE4 mRNA CTD PMID:27594783 cisplatin increases expression ISO RGD:733230 6480464 Cisplatin results in increased expression of TLE4 mRNA CTD PMID:27392435 copper(II) sulfate affects expression ISO RGD:733230 6480464 Copper Sulfate affects the expression of TLE4 mRNA CTD PMID:19549813 crocidolite asbestos increases expression ISO RGD:733230 6480464 Asbestos, Crocidolite results in increased expression of TLE4 mRNA CTD PMID:18687144 dexamethasone decreases expression ISO RGD:733230 6480464 Dexamethasone results in decreased expression of TLE4 mRNA CTD PMID:12782123 dorsomorphin multiple interactions ISO RGD:733230 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 entinostat decreases expression ISO RGD:733230 6480464 entinostat results in decreased expression of TLE4 mRNA CTD PMID:26272509 entinostat multiple interactions ISO RGD:733230 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TLE4 mRNA CTD PMID:27188386 ethanol affects splicing EXP 6480464 Ethanol affects the splicing of TLE4 mRNA CTD PMID:30319688 ethyl methanesulfonate increases expression ISO RGD:733230 6480464 Ethyl Methanesulfonate results in increased expression of TLE4 mRNA CTD PMID:23649840 fonofos increases methylation ISO RGD:733230 6480464 Fonofos results in increased methylation of TLE4 promoter CTD PMID:22847954 formaldehyde increases expression ISO RGD:733230 6480464 Formaldehyde results in increased expression of TLE4 mRNA CTD PMID:20655997 , PMID:23649840 geldanamycin increases expression ISO RGD:733230 6480464 geldanamycin results in increased expression of TLE4 mRNA CTD PMID:26705709 gentamycin increases expression ISO RGD:3868 6480464 Gentamicins results in increased expression of TLE4 mRNA CTD PMID:22061828 methyl methanesulfonate increases expression ISO RGD:733230 6480464 Methyl Methanesulfonate results in increased expression of TLE4 mRNA CTD PMID:23649840 methylmercury chloride increases expression ISO RGD:733230 6480464 methylmercuric chloride results in increased expression of TLE4 mRNA CTD PMID:23179753 , PMID:27188386 nickel sulfate increases expression ISO RGD:733230 6480464 nickel sulfate results in increased expression of TLE4 mRNA CTD PMID:22714537 oxaliplatin multiple interactions ISO RGD:3868 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of TLE4 mRNA CTD PMID:25729387 panobinostat multiple interactions ISO RGD:733230 6480464 [NOG protein co-treated with Panobinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TLE4 mRNA CTD PMID:27188386 panobinostat decreases expression ISO RGD:733230 6480464 panobinostat results in decreased expression of TLE4 mRNA CTD PMID:26272509 paracetamol affects expression ISO RGD:733230 6480464 Acetaminophen affects the expression of TLE4 mRNA CTD PMID:25458485 paracetamol increases expression ISO RGD:733230 6480464 Acetaminophen results in increased expression of TLE4 mRNA CTD PMID:29067470 parathion increases methylation ISO RGD:733230 6480464 Parathion results in increased methylation of TLE4 promoter CTD PMID:22847954 phenylmercury acetate decreases expression ISO RGD:733230 6480464 Phenylmercuric Acetate results in decreased expression of TLE4 mRNA CTD PMID:26272509 phenylmercury acetate multiple interactions ISO RGD:733230 6480464 [NOG protein co-treated with Phenylmercuric Acetate co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TLE4 mRNA CTD PMID:27188386 PhIP increases expression ISO RGD:3868 6480464 2-amino-1-methyl-6-phenylimidazo(4, 5-b)pyridine results in increased expression of TLE4 mRNA CTD PMID:12376462 pirinixic acid decreases expression EXP 6480464 pirinixic acid results in decreased expression of TLE4 mRNA CTD PMID:20059764 pirinixic acid multiple interactions EXP 6480464 PPARA protein promotes the reaction [pirinixic acid results in decreased expression of TLE4 mRNA] CTD PMID:20059764 potassium chromate multiple interactions ISO RGD:733230 6480464 [potassium chromate(VI) co-treated with epigallocatechin gallate] results in decreased expression of TLE4 mRNA CTD PMID:22079256 potassium chromate increases expression ISO RGD:733230 6480464 potassium chromate(VI) results in increased expression of TLE4 mRNA CTD PMID:22714537 potassium chromate decreases expression ISO RGD:733230 6480464 potassium chromate(VI) results in decreased expression of TLE4 mRNA CTD PMID:22079256 rotenone affects expression ISO RGD:3868 6480464 Rotenone affects the expression of TLE4 mRNA CTD PMID:27900601 SB 431542 multiple interactions ISO RGD:733230 6480464 [NOG protein co-treated with entinostat co-treated with dorsomorphin co-treated with 4-(5-benzo(1 more ... CTD PMID:27188386 silver atom decreases expression EXP 6480464 Silver results in decreased expression of TLE4 mRNA CTD PMID:27131904 silver(0) decreases expression EXP 6480464 Silver results in decreased expression of TLE4 mRNA CTD PMID:27131904 terbufos increases methylation ISO RGD:733230 6480464 terbufos results in increased methylation of TLE4 promoter CTD PMID:22847954 tert-butyl hydroperoxide decreases expression ISO RGD:733230 6480464 tert-Butylhydroperoxide results in decreased expression of TLE4 mRNA CTD PMID:15336504 thimerosal decreases expression ISO RGD:733230 6480464 Thimerosal results in decreased expression of TLE4 mRNA CTD PMID:27188386 topotecan multiple interactions ISO RGD:3868 6480464 [oxaliplatin co-treated with Topotecan] results in decreased expression of TLE4 mRNA CTD PMID:25729387 topotecan decreases expression ISO RGD:3868 6480464 Topotecan results in decreased expression of TLE4 mRNA CTD PMID:25729387 torcetrapib increases expression ISO RGD:733230 6480464 torcetrapib results in increased expression of TLE4 mRNA CTD PMID:23228038 trichostatin A decreases expression ISO RGD:733230 6480464 trichostatin A results in decreased expression of TLE4 mRNA CTD PMID:24935251 , PMID:26272509 trichostatin A multiple interactions ISO RGD:733230 6480464 [NOG protein co-treated with trichostatin A co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TLE4 mRNA CTD PMID:27188386 troglitazone decreases expression EXP 6480464 troglitazone results in decreased expression of TLE4 mRNA CTD PMID:28973697 urethane increases expression ISO RGD:733230 6480464 Urethane results in increased expression of TLE4 mRNA CTD PMID:28818685 valproic acid decreases expression EXP 6480464 Valproic Acid analog results in decreased expression of TLE4 mRNA, Valproic Acid results in decreased expression of TLE4 mRNA CTD PMID:21427059 valproic acid decreases expression ISO RGD:733230 6480464 Valproic Acid results in decreased expression of TLE4 mRNA CTD PMID:23179753 , PMID:26272509 valproic acid multiple interactions ISO RGD:733230 6480464 [NOG protein co-treated with Valproic Acid co-treated with dorsomorphin co-treated with 4-(5-benzo(1, 3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide] results in decreased expression of TLE4 mRNA CTD PMID:27188386 vorinostat decreases expression ISO RGD:733230 6480464 vorinostat results in decreased expression of TLE4 mRNA CTD PMID:27188386 zoledronic acid increases expression ISO RGD:733230 6480464 zoledronic acid results in increased expression of TLE4 mRNA CTD PMID:24714768 
Gene-Chemical Interaction Annotations
