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Gene: Tle4 (transducin-like enhancer of split 4) Mus musculus
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Symbol: Tle4
Name: transducin-like enhancer of split 4
Description: Exhibits several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; repressing transcription factor binding activity; and transcription corepressor activity. Involved in Wnt signaling pathway; cellular response to leukemia inhibitory factor; and negative regulation of transcription by RNA polymerase II. Localizes to the nucleus. Is expressed in several structures, including central nervous system; genitourinary system; peripheral nervous system ganglion; sensory organ; and trunk mesenchyme. Orthologous to human TLE4 (TLE family member 4, transcriptional corepressor); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxyphenyl retinamide; 5-aza-2'-deoxycytidine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 5730411M05Rik; AA792082; B lymphocyte gene 1; Bce-1; Bce1; ESTM13; ESTM14; grg-4; Grg4; groucho-related protein 4; transducin-like enhancer of split 4, homolog of Drosophila E(spl); transducin-like enhancer protein 4; X83332; X83333
Orthologs:
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm381914,448,072 - 14,598,183 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371914,522,562 - 14,672,473 (-)NCBIGRCm37mm9NCBIm37
MGSCv361914,515,091 - 14,665,002 (-)NCBImm8
Celera1915,104,678 - 15,255,003 (-)NCBICelera
Cytogenetic Map19 ANCBI
cM Map199.11NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Tle4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 11422
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.