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Gene: Tnf (tumor necrosis factor) Mus musculus
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Symbol: Tnf
Name: tumor necrosis factor
Description: Exhibits cytokine activity; protease binding activity; and tumor necrosis factor receptor binding activity. Involved in several processes, including apoptotic signaling pathway; positive regulation of intracellular signal transduction; and positive regulation of macromolecule metabolic process. Localizes to several cellular components, including the external side of plasma membrane; phagocytic cup; and recycling endosome. Used to study several diseases, including bone disease (multiple); congestive heart failure; heart valve disease (multiple); idiopathic pulmonary fibrosis; and multiple sclerosis. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune hypersensitivity disease (multiple); eye disease (multiple); lung disease (multiple); and skin disease (multiple). Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and lung. Orthologous to human TNF (tumor necrosis factor).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: cachectin; DIF; MGC151434; TNF alpha; TNF-a; TNF-alpha; Tnfa; TNFalpha; Tnfsf1a; TNFSF2; Tnlg1f; tumor necrosis factor alpha; tumor necrosis factor ligand 1f; tumor necrosis factor ligand superfamily member 2; tumor necrosis factor-alpha
Orthologs:
Homo sapiens (human) : TNF (tumor necrosis factor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tnf (tumor necrosis factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tnf (tumor necrosis factor)
Pan paniscus (bonobo/pygmy chimpanzee) : TNF (tumor necrosis factor)
Canis lupus familiaris (dog) : TNF (tumor necrosis factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tnf (tumor necrosis factor)
Sus scrofa (pig) : TNF (tumor necrosis factor)
Heterocephalus glaber (naked mole-rat) : Tnf (tumor necrosis factor)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1735,199,381 - 35,202,007 (-)Ensembl
GRCm381735,199,367 - 35,202,007 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371735,336,335 - 35,338,941 (-)NCBIGRCm37mm9NCBIm37
MGSCv361734,807,442 - 34,810,048 (-)NCBImm8
Celera1738,296,067 - 38,298,710 (-)NCBICelera
Cytogenetic Map17B1NCBI
cM Map1718.59NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model