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Gene: Trhr (thyrotropin releasing hormone receptor) Mus musculus
Symbol: Trhr
Name: thyrotropin releasing hormone receptor
Description: Predicted to have protein homodimerization activity and thyrotropin-releasing hormone receptor activity. Predicted to be involved in phospholipase C-activating G protein-coupled receptor signaling pathway; positive regulation of cytosolic calcium ion concentration; and positive regulation of protein homodimerization activity. Predicted to localize to the cell surface. Used to study congenital hypothyroidism. Human ortholog(s) of this gene implicated in congenital hypothyroidism and hypertension. Is expressed in several structures, including alimentary system; brain; heart; sensory organ; and skeleton. Orthologous to human TRHR (thyrotropin releasing hormone receptor); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; dibutyl phthalate; morphine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: MGC124380; MGC124381; thyroliberin receptor; thyrotropin-releasing hormone receptor; TRH-R; TRH-R1
Homo sapiens (human) : TRHR (thyrotropin releasing hormone receptor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Trhr (thyrotropin releasing hormone receptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Trhr (thyrotropin releasing hormone receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : TRHR (thyrotropin releasing hormone receptor)
Canis lupus familiaris (dog) : TRHR (thyrotropin releasing hormone receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Trhr (thyrotropin releasing hormone receptor)
Sus scrofa (pig) : TRHR (thyrotropin releasing hormone receptor)
Chlorocebus sabaeus (African green monkey) : TRHR (thyrotropin releasing hormone receptor)
Heterocephalus glaber (naked mole-rat) : Trhr (thyrotropin releasing hormone receptor)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1544,196,135 - 44,235,912 (+)EnsemblGRCm38mm10GRCm38
GRCm381544,195,924 - 44,235,912 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371544,027,681 - 44,067,458 (+)NCBIGRCm37mm9NCBIm37
MGSCv361544,026,307 - 44,065,986 (+)NCBImm8
Celera1544,658,539 - 44,700,386 (+)NCBICelera
Cytogenetic Map15B3.2NCBI
cM Map1516.82NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Trhr
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 11453
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.