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Gene: Tshr (thyroid stimulating hormone receptor) Mus musculus
Symbol: Tshr
Name: thyroid stimulating hormone receptor
Description: Exhibits thyroid-stimulating hormone receptor activity. Involved in several processes, including inner ear development; positive regulation of cold-induced thermogenesis; and positive regulation of growth. Localizes to the plasma membrane. Used to study congenital hypothyroidism. Human ortholog(s) of this gene implicated in Graves' disease; cardiomyopathy; congenital nongoitrous hypothyroidism 1; and mitral valve prolapse. Is expressed in bladder; renal vasculature; thyroid gland; and thyroid gland lobe. Orthologous to human TSHR (thyroid stimulating hormone receptor); PARTICIPATES IN autoimmune thyroiditis pathway; INTERACTS WITH 17beta-estradiol; 4-hydroxyphenyl retinamide; thyroxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: AI481368; expressed sequence AI481368; hypothroid; hyt; pet; thyroid-stimulating hormone receptor; thyrotropin receptor; TSH-R
Homo sapiens (human) : TSHR (thyroid stimulating hormone receptor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : LOC103692150 (thyrotropin receptor pseudogene)
Chinchilla lanigera (long-tailed chinchilla) : Tshr (thyroid stimulating hormone receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : TSHR (thyroid stimulating hormone receptor)
Canis lupus familiaris (dog) : TSHR (thyroid stimulating hormone receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tshr (thyroid stimulating hormone receptor)
Sus scrofa (pig) : TSHR (thyroid stimulating hormone receptor)
Chlorocebus sabaeus (African green monkey) : TSHR (thyroid stimulating hormone receptor)
Heterocephalus glaber (naked mole-rat) : Tshr (thyroid stimulating hormone receptor)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1291,384,563 - 91,549,808 (+)EnsemblGRCm38mm10GRCm38
GRCm381291,400,993 - 91,540,509 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371292,639,433 - 92,778,949 (+)NCBIGRCm37mm9NCBIm37
MGSCv361291,806,608 - 91,945,435 (+)NCBImm8
Celera1292,722,330 - 92,841,955 (+)NCBICelera
Cytogenetic Map12D3NCBI
cM Map1244.51NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Tshr
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 11458
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-03-04
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.