Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Tyr (tyrosinase) Mus musculus
Analyze
Symbol: Tyr
Name: tyrosinase
Description: Exhibits protein homodimerization activity. Involved in several processes, including melanin biosynthetic process; pigmentation; and thymus development. Localizes to melanosome. Is expressed in central nervous system; eye; head mesenchyme; mesenchyme derived from neural crest; and skin. Used to study buphthalmos and oculocutaneous albinism. Human ortholog(s) of this gene implicated in melanoma (multiple); ocular albinism; oculocutaneous albinism (multiple); retinoschisis; and vitiligo. Orthologous to human TYR (tyrosinase); PARTICIPATES IN alkaptonuria pathway; disulfiram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; INTERACTS WITH 17beta-estradiol; 1H-imidazole; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: albino; albino locus protein; c; monophenol monooxygenase; Oca1; skc35
Orthologs:
Homo sapiens (human) : TYR (tyrosinase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tyr (tyrosinase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tyr (tyrosinase)
Pan paniscus (bonobo/pygmy chimpanzee) : TYR (tyrosinase)
Canis lupus familiaris (dog) : TYR (tyrosinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tyr (tyrosinase)
Sus scrofa (pig) : TYR (tyrosinase)
Chlorocebus sabaeus (African green monkey) : TYR (tyrosinase)
Heterocephalus glaber (naked mole-rat) : Tyr (tyrosinase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl787,424,771 - 87,493,512 (-)EnsemblGRCm38mm10GRCm38
GRCm38787,424,771 - 87,493,512 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37794,575,915 - 94,641,921 (-)NCBIGRCm37mm9NCBIm37
MGSCv36787,303,166 - 87,369,172 (-)NCBImm8
Celera784,786,868 - 84,854,808 (-)NCBICelera
Cytogenetic Map7D3NCBI
cM Map749.01NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Tyr
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 11466
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-06-19
Status: ACTIVE



NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.