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Gene: Tyr (tyrosinase) Mus musculus
Symbol: Tyr
Name: tyrosinase
Description: Exhibits protein homodimerization activity. Involved in several processes, including melanin biosynthetic process; pigmentation; and thymus development. Localizes to melanosome. Is expressed in central nervous system; eye; head mesenchyme; mesenchyme derived from neural crest; and skin. Used to study buphthalmos and oculocutaneous albinism. Human ortholog(s) of this gene implicated in melanoma (multiple); ocular albinism; oculocutaneous albinism (multiple); retinoschisis; and vitiligo. Orthologous to human TYR (tyrosinase); PARTICIPATES IN alkaptonuria pathway; disulfiram pharmacodynamics pathway; dopamine beta-hydroxylase deficiency pathway; INTERACTS WITH 17beta-estradiol; 1H-imidazole; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: albino; albino locus protein; c; monophenol monooxygenase; Oca1; skc35
Homo sapiens (human) : TYR (tyrosinase)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tyr (tyrosinase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tyr (tyrosinase)
Pan paniscus (bonobo/pygmy chimpanzee) : TYR (tyrosinase)
Canis lupus familiaris (dog) : TYR (tyrosinase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tyr (tyrosinase)
Sus scrofa (pig) : TYR (tyrosinase)
Chlorocebus sabaeus (African green monkey) : TYR (tyrosinase)
Heterocephalus glaber (naked mole-rat) : Tyr (tyrosinase)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl787,424,771 - 87,493,512 (-)EnsemblGRCm38mm10GRCm38
GRCm38787,424,771 - 87,493,512 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37794,575,915 - 94,641,921 (-)NCBIGRCm37mm9NCBIm37
MGSCv36787,303,166 - 87,369,172 (-)NCBImm8
Celera784,786,868 - 84,854,808 (-)NCBICelera
Cytogenetic Map7D3NCBI
cM Map749.01NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Tyr
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 11466
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-06-19
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.