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Gene: Vhl (von Hippel-Lindau tumor suppressor) Mus musculus
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Symbol: Vhl
Name: von Hippel-Lindau tumor suppressor
Description: Predicted to have enzyme binding activity; transcription factor binding activity; and ubiquitin protein ligase activity. Involved in several processes, including animal organ development; homeostasis of number of retina cells; and regulation of apoptotic process. Localizes to several cellular components, including Cul2-RING ubiquitin ligase complex; glutamatergic synapse; and nuclear lumen. Used to study familial erythrocytosis 2; sudden infant death syndrome; and von Hippel-Lindau disease. Human ortholog(s) of this gene implicated in several diseases, including pancreatic cancer (multiple); pheochromocytoma; polycythemia (multiple); renal cell carcinoma; and von Hippel-Lindau disease. Is expressed in several structures, including eye; genitourinary system; gut; heart; and nervous system. Orthologous to several human genes including VHL (von Hippel-Lindau tumor suppressor); PARTICIPATES IN altered hypoxia inducible factor pathway; hypoxia inducible factor pathway; proteasome degradation pathway involving cullin-dependent ubiquitin ligases; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: pVHL; Vhlh; von Hippel-Lindau disease tumor suppressor; von Hippel-Lindau syndrome homolog; von Hippel-Lindau syndrome protein homolog
Orthologs:
Homo sapiens (human) : VHL (von Hippel-Lindau tumor suppressor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Vhl (von Hippel-Lindau tumor suppressor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Vhl (von Hippel-Lindau tumor suppressor)
Pan paniscus (bonobo/pygmy chimpanzee) : VHL (von Hippel-Lindau tumor suppressor)
Canis lupus familiaris (dog) : VHL (von Hippel-Lindau tumor suppressor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Vhl (von Hippel-Lindau tumor suppressor)
Sus scrofa (pig) : VHL (von Hippel-Lindau tumor suppressor)
Chlorocebus sabaeus (African green monkey) : VHL (von Hippel-Lindau tumor suppressor)
Heterocephalus glaber (naked mole-rat) : Vhl (von Hippel-Lindau tumor suppressor)
more info ...
Related Pseudogenes: Vhl-ps1  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl6113,623,959 - 113,631,633 (+)EnsemblGRCm38mm10GRCm38
GRCm386113,623,994 - 113,631,634 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv376113,574,015 - 113,581,627 (+)NCBIGRCm37mm9NCBIm37
MGSCv366113,589,798 - 113,597,410 (+)NCBImm8
Celera6115,450,882 - 115,458,459 (+)NCBICelera
Cytogenetic Map6E3NCBI
cM Map652.81NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
Nomenclature History
 
More on Vhl
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 11485
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-05-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.