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Gene: Wt1 (Wilms tumor 1 homolog) Mus musculus
Symbol: Wt1
Name: Wilms tumor 1 homolog
CRRD ID: 11493
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific; RNA binding activity; and double-stranded DNA binding activity. Involved in several processes, including animal organ development; regulation of gonad development; and regulation of metanephros development. Localizes to cytoplasm and nucleus. Is expressed in several structures, including alimentary system; body cavity or lining; central nervous system; genitourinary system; and trunk. Used to study Denys-Drash syndrome and congenital diaphragmatic hernia. Human ortholog(s) of this gene implicated in several diseases, including Denys-Drash syndrome; Frasier syndrome; malignant mesothelioma; nephroblastoma; and nephrotic syndrome type 4. Orthologous to human WT1 (WT1 transcription factor).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: D630046I19Rik; Wilms tumor homolog; Wilms tumor protein homolog; Wt-1
Homo sapiens (human) : WT1 (WT1 transcription factor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Wt1 (WT1 transcription factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Wt1 (WT1 transcription factor)
Pan paniscus (bonobo/pygmy chimpanzee) : WT1 (WT1 transcription factor)
Canis lupus familiaris (dog) : WT1 (WT1 transcription factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Wt1 (WT1 transcription factor)
Sus scrofa (pig) : WT1 (WT1 transcription factor)
Chlorocebus sabaeus (African green monkey) : WT1 (WT1 transcription factor)
Heterocephalus glaber (naked mole-rat) : Wt1 (WT1 transcription factor)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm392104,956,874 - 105,003,959 (+)NCBI
GRCm382105,126,529 - 105,173,614 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2105,126,529 - 105,173,616 (+)EnsemblGRCm38mm10GRCm38
MGSCv372104,966,686 - 105,013,771 (+)NCBIGRCm37mm9NCBIm37
MGSCv362104,927,368 - 104,974,451 (+)NCBImm8
Celera2106,361,212 - 106,408,919 (+)NCBICelera
Cytogenetic Map2E2-E3NCBI
cM Map255.06NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Wt1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 11493
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-10-13
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.