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Gene: Wt1 (Wilms tumor 1 homolog) Mus musculus
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Symbol: Wt1
Name: Wilms tumor 1 homolog
Description: Exhibits DNA-binding transcription activator activity, RNA polymerase II-specific; RNA binding activity; and double-stranded DNA binding activity. Involved in several processes, including animal organ development; regulation of gonad development; and regulation of metanephros development. Localizes to the cytoplasm and nucleus. Used to study Denys-Drash syndrome and congenital diaphragmatic hernia. Human ortholog(s) of this gene implicated in several diseases, including Denys-Drash syndrome; Frasier syndrome; malignant mesothelioma; nephroblastoma; and nephrotic syndrome type 4. Is expressed in several structures, including alimentary system; body cavity or lining; central nervous system; genitourinary system; and trunk. Orthologous to human WT1 (WT1 transcription factor).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: D630046I19Rik; Wilms tumor homolog; Wilms tumor protein homolog; Wt-1
Orthologs:
Homo sapiens (human) : WT1 (WT1 transcription factor)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Wt1 (WT1 transcription factor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Wt1 (WT1 transcription factor)
Pan paniscus (bonobo/pygmy chimpanzee) : WT1 (WT1 transcription factor)
Canis lupus familiaris (dog) : WT1 (WT1 transcription factor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Wt1 (WT1 transcription factor)
Sus scrofa (pig) : WT1 (WT1 transcription factor)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm382105,126,529 - 105,173,614 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv372104,966,686 - 105,013,771 (+)NCBIGRCm37mm9NCBIm37
MGSCv362104,927,368 - 104,974,451 (+)NCBImm8
Celera2106,361,212 - 106,408,919 (+)NCBICelera
Cytogenetic Map2 E2-E3NCBI
cM Map255.06NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Wt1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 11493
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-10-29
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.