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Gene: Ywhaz (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide) Mus musculus
Symbol: Ywhaz
Name: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide
Description: Exhibits protein domain specific binding activity. Involved in several processes, including ERK1 and ERK2 cascade; synaptic target recognition; and tube morphogenesis. Localizes to hippocampal mossy fiber to CA3 synapse and nucleus. Used to study schizophrenia. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and hemolymphoid system gland. Orthologous to human YWHAZ (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta); PARTICIPATES IN granulocyte-macrophage colony-stimulating factor signaling pathway; histone modification pathway; insulin responsive facilitative sugar transporter mediated glucose transport pathway; INTERACTS WITH 2,2',4,4',5,5'-hexachlorobiphenyl; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1110013I11Rik; 14-3-3 protein zeta/delta; 14-3-3 zeta; 14-3-3zeta; AI596267; AL022924; AU020854; KCIP-1; protein kinase C inhibitor protein 1; SEZ-2
Related Pseudogenes: Gm19228   Gm5279  
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1536,770,770 - 36,796,929 (-)EnsemblGRCm38mm10GRCm38
GRCm381536,770,261 - 36,802,984 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371536,700,016 - 36,724,293 (-)NCBIGRCm37mm9NCBIm37
MGSCv361536,715,359 - 36,738,833 (-)NCBImm8
Celera1537,392,750 - 37,416,932 (-)NCBICelera
Cytogenetic Map15B3.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Ywhaz
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 11498
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.