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Gene: Fmr1em1Sage (fragile X mental retardation 1;zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs) Rattus norvegicus
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Symbol: Fmr1em1Sage
Name: fragile X mental retardation 1;zinc finger nuclease induced mutant 1, Sigma Advanced Genetic Engineering Labs
Description: The ZFN mutant allele was produced by injecting zinc finger nuclease targeting rat Fmr1 into Sprague Dawley embryos. The resulting mutation was a 122bp deletion of the intron 7/exon8 junction occurred at 18533bp-18654bp and caused knockout of Fmr1 demonstrated by western blot.
ASSOCIATED WITH abnormal social play behavior; enlarged testis; increased gnawing activity; ASSOCIATED WITH autism spectrum disorder
Type: allele  of Fmr1  
Also known as: Fmr1em1Sage
Is Marker For: Strains:   SD-Fmr1em1Sage  
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position: No map positions available.


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References - curated

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Sequence

Nucleotide Sequences

Additional Information

 
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CRRD Object Information
CRRD ID: 11568041
Created: 2016-12-06
Species: Rattus norvegicus
Last Modified: 2016-12-06
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.