RPS6KB1 (ribosomal protein S6 kinase B1) - Chinchilla Research Resource Database
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Gene: RPS6KB1 (ribosomal protein S6 kinase B1) Pan paniscus
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Symbol: RPS6KB1
Name: ribosomal protein S6 kinase B1
CRRD ID: 11704745
Description: ENCODES a protein that exhibits ATP binding (ortholog); identical protein binding (ortholog); PDZ domain binding (ortholog); INVOLVED IN aging (ortholog); behavioral fear response (ortholog); cell migration (ortholog); PARTICIPATES IN insulin signaling pathway; insulin-like growth factor signaling pathway; interleukin-4 signaling pathway; ASSOCIATED WITH Atrophy (ortholog); autosomal dominant polycystic kidney disease (ortholog); Burns (ortholog); FOUND IN cell surface (ortholog); cytoplasm (ortholog); cytosol (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOW QUALITY PROTEIN: ribosomal protein S6 kinase beta-1; ribosomal protein S6 kinase beta-1
Orthologs:
Homo sapiens (human) : RPS6KB1 (ribosomal protein S6 kinase B1)  HGNC  Alliance
Mus musculus (house mouse) : Rps6kb1 (ribosomal protein S6 kinase, polypeptide 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Rps6kb1 (ribosomal protein S6 kinase B1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Rps6kb1 (ribosomal protein S6 kinase B1)
Canis lupus familiaris (dog) : RPS6KB1 (ribosomal protein S6 kinase B1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Rps6kb1 (ribosomal protein S6 kinase B1)
Sus scrofa (pig) : RPS6KB1 (ribosomal protein S6 kinase B1)
Chlorocebus sabaeus (African green monkey) : RPS6KB1 (ribosomal protein S6 kinase B1)
Heterocephalus glaber (naked mole-rat) : Rps6kb1 (ribosomal protein S6 kinase B1)
more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11758,798,930 - 58,856,480 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1758,799,069 - 58,853,653 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01753,958,807 - 54,014,752 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
aging  (ISO)
behavioral fear response  (ISO)
cell migration  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to hormone stimulus  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to interferon-gamma  (ISO)
cellular response to organic cyclic compound  (ISO)
G1/S transition of mitotic cell cycle  (ISO)
germ cell development  (ISO)
long-chain fatty acid import into cell  (ISO)
long-term memory  (ISO)
negative regulation of apoptotic process  (ISO)
negative regulation of extrinsic apoptotic signaling pathway  (ISO)
negative regulation of insulin receptor signaling pathway  (ISO)
peptidyl-serine phosphorylation  (ISO)
positive regulation of mitotic cell cycle  (ISO)
positive regulation of skeletal muscle tissue growth  (ISO)
positive regulation of smooth muscle cell migration  (ISO)
positive regulation of smooth muscle cell proliferation  (ISO)
positive regulation of translation  (ISO)
positive regulation of translational initiation  (ISO)
protein kinase B signaling  (ISO)
protein phosphorylation  (ISO)
regulation of glucose import  (ISO)
response to amino acid  (ISO)
response to drug  (ISO)
response to electrical stimulus involved in regulation of muscle adaptation  (ISO)
response to ethanol  (ISO)
response to glucagon  (ISO)
response to glucocorticoid  (ISO)
response to glucose  (ISO)
response to heat  (ISO)
response to insulin  (ISO)
response to leucine  (ISO)
response to lipopolysaccharide  (ISO)
response to mechanical stimulus  (ISO)
response to nutrient  (ISO)
response to nutrient levels  (ISO)
response to organic cyclic compound  (ISO)
response to organic substance  (ISO)
response to organonitrogen compound  (ISO)
response to peptide hormone  (ISO)
response to testosterone  (ISO)
response to toxic substance  (ISO)
response to tumor necrosis factor  (ISO)
response to wounding  (ISO)
skeletal muscle atrophy  (ISO)
skeletal muscle contraction  (ISO)
TOR signaling  (ISO)

Cellular Component

References

Genomics

Comparative Map Data
RPS6KB1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11758,798,930 - 58,856,480 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1758,799,069 - 58,853,653 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01753,958,807 - 54,014,752 (+)NCBI
RPS6KB1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1759,893,046 - 59,950,574 (+)EnsemblGRCh38hg38GRCh38
GRCh381759,893,121 - 59,950,574 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371757,970,407 - 58,027,787 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361755,325,225 - 55,382,569 (+)NCBINCBI36hg18NCBI36
Build 341755,325,224 - 55,382,566NCBI
Celera1754,433,949 - 54,491,301 (+)NCBI
Cytogenetic Map17q23.1NCBI
HuRef1753,342,941 - 53,400,248 (+)NCBIHuRef
CHM1_11758,034,428 - 58,091,804 (+)NCBICHM1_1
Rps6kb1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391186,389,695 - 86,435,711 (-)NCBI
GRCm381186,498,869 - 86,544,885 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1186,498,871 - 86,544,805 (-)EnsemblGRCm38mm10GRCm38
MGSCv371186,312,511 - 86,358,309 (-)NCBIGRCm37mm9NCBIm37
MGSCv361186,330,178 - 86,360,969 (-)NCBImm8
Celera1196,115,093 - 96,160,675 (-)NCBICelera
Cytogenetic Map11CNCBI
Rps6kb1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01073,824,200 - 73,865,503 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1073,824,202 - 73,865,364 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01076,234,192 - 76,278,394 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41076,657,024 - 76,698,088 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11076,671,395 - 76,712,458 (-)NCBI
Celera1070,248,523 - 70,289,589 (-)NCBICelera
Cytogenetic Map10q26NCBI
Rps6kb1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0NW_0049554513,181,085 - 3,225,610 (-)NCBIChiLan1.0ChiLan1.0
RPS6KB1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl934,387,091 - 34,425,292 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1934,387,084 - 34,590,603 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Rps6kb1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049364903,441,046 - 3,492,917 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
RPS6KB1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.11236,111,584 - 36,159,287 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21237,386,770 - 37,434,407 (+)NCBISscrofa10.2Sscrofa10.2susScr3
RPS6KB1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1633,497,392 - 33,556,453 (-)Ensembl
ChlSab1.11633,498,098 - 33,556,553 (-)NCBI
Rps6kb1
(Heterocephalus glaber - naked mole-rat)
No map positions available.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_034942600   ⟹   XP_034798491
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01753,958,812 - 54,014,752 (+)NCBI
RefSeq Acc Id: XM_034942601   ⟹   XP_034798492
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01753,958,882 - 54,014,752 (+)NCBI
RefSeq Acc Id: XM_034942602   ⟹   XP_034798493
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01753,958,807 - 54,014,752 (+)NCBI
RefSeq Acc Id: XM_034942603   ⟹   XP_034798494
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01753,974,252 - 54,014,752 (+)NCBI
RefSeq Acc Id: XM_034942605   ⟹   XP_034798496
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01753,958,882 - 54,014,752 (+)NCBI
RefSeq Acc Id: XM_034942606   ⟹   XP_034798497
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01753,958,852 - 53,996,215 (+)NCBI
RefSeq Acc Id: XM_034942607   ⟹   XP_034798498
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01753,958,851 - 53,996,055 (+)NCBI
RefSeq Acc Id: XR_004667288
RefSeq Status:
Type: NON-CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v01753,958,882 - 54,014,752 (+)NCBI
Reference Sequences
RefSeq Acc Id: XP_034798493   ⟸   XM_034942602
- Peptide Label: isoform X3
RefSeq Acc Id: XP_034798491   ⟸   XM_034942600
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034798498   ⟸   XM_034942607
- Peptide Label: isoform X6
RefSeq Acc Id: XP_034798497   ⟸   XM_034942606
- Peptide Label: isoform X5
RefSeq Acc Id: XP_034798496   ⟸   XM_034942605
- Peptide Label: isoform X4
RefSeq Acc Id: XP_034798492   ⟸   XM_034942601
- Peptide Label: isoform X2
RefSeq Acc Id: XP_034798494   ⟸   XM_034942603
- Peptide Label: isoform X3

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000028449 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000010471 UniProtKB/TrEMBL
  ENSPPAP00000010476 UniProtKB/TrEMBL
  ENSPPAP00000010478 UniProtKB/TrEMBL
  ENSPPAP00000010482 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000033121 UniProtKB/TrEMBL
  ENSPPAT00000033126 UniProtKB/TrEMBL
  ENSPPAT00000033128 UniProtKB/TrEMBL
  ENSPPAT00000033132 UniProtKB/TrEMBL
InterPro AGC-kinase_C UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Pkinase_C UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Protein_kinase_ATP_BS UniProtKB/TrEMBL
  Ribosomal_S6_kinase UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
NCBI Gene RPS6KB1 ENTREZGENE
Pfam Pkinase UniProtKB/TrEMBL
  Pkinase_C UniProtKB/TrEMBL
PIRSF Ribsml_S6_kin_1 UniProtKB/TrEMBL
PROSITE AGC_KINASE_CTER UniProtKB/TrEMBL
  PROTEIN_KINASE_ATP UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
SMART S_TK_X UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
UniProt A0A2R8ZZQ8_PANPA UniProtKB/TrEMBL
  A0A2R8ZZR2_PANPA UniProtKB/TrEMBL
  A0A2R8ZZR7_PANPA UniProtKB/TrEMBL
  A0A2R9A0W0_PANPA UniProtKB/TrEMBL

 



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.