EDNRA (endothelin receptor type A) - Chinchilla Research Resource Database
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Gene: EDNRA (endothelin receptor type A) Pan paniscus
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Symbol: EDNRA
Name: endothelin receptor type A
CRRD ID: 11719923
Description: ENCODES a protein that exhibits endothelin receptor activity (ortholog); INVOLVED IN adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway (ortholog); aging (ortholog); artery smooth muscle contraction (ortholog); PARTICIPATES IN endothelin signaling pathway; inflammatory response pathway; Rho/Rac/Cdc42 mediated signaling pathway; ASSOCIATED WITH asthma (ortholog); Cardiovascular Abnormalities (ortholog); congenital heart disease (ortholog); FOUND IN membrane (ortholog); membrane raft (ortholog); nuclear membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: endothelin-1 receptor
Orthologs:
Homo sapiens (human) : EDNRA (endothelin receptor type A)  HGNC  Alliance
Mus musculus (house mouse) : Ednra (endothelin receptor type A)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ednra (endothelin receptor type A)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ednra (endothelin receptor type A)
Canis lupus familiaris (dog) : EDNRA (endothelin receptor type A)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ednra (endothelin receptor type A)
Sus scrofa (pig) : EDNRA (endothelin receptor type A)
Chlorocebus sabaeus (African green monkey) : EDNRA (endothelin receptor type A)
Heterocephalus glaber (naked mole-rat) : Ednra (endothelin receptor type A)
more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14151,476,353 - 151,536,497 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4151,476,356 - 151,536,497 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04139,815,336 - 139,879,600 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway  (ISO)
aging  (ISO)
artery smooth muscle contraction  (ISO)
branching involved in blood vessel morphogenesis  (ISO)
cellular response to mechanical stimulus  (ISO)
fibroblast proliferation  (ISO)
glomerular filtration  (ISO)
head development  (ISO)
heart development  (ISO)
histamine secretion  (ISO)
in utero embryonic development  (ISO)
maternal process involved in parturition  (ISO)
negative regulation of apoptotic process  (ISO)
neural crest cell development  (ISO)
penile erection  (ISO)
positive regulation of calcium ion transport  (ISO)
positive regulation of cell population proliferation  (ISO)
positive regulation of cytosolic calcium ion concentration  (ISO)
positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway  (ISO)
positive regulation of ERK1 and ERK2 cascade  (ISO)
positive regulation of inflammatory response  (ISO)
positive regulation of kidney development  (ISO)
positive regulation of neutrophil chemotaxis  (ISO)
positive regulation of odontogenesis  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of release of sequestered calcium ion into cytosol  (ISO)
protein kinase C-activating G protein-coupled receptor signaling pathway  (ISO)
regulation of blood pressure  (ISO)
regulation of epithelial cell proliferation  (ISO)
regulation of glucose transmembrane transport  (ISO)
respiratory gaseous exchange by respiratory system  (ISO)
response to hypoxia  (ISO)
response to lipopolysaccharide  (ISO)
response to morphine  (ISO)
response to organic cyclic compound  (ISO)
Rho protein signal transduction  (ISO)
sensory perception of pain  (ISO)
smooth muscle cell proliferation  (ISO)
vasoconstriction  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
EDNRA
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14151,476,353 - 151,536,497 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4151,476,356 - 151,536,497 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04139,815,336 - 139,879,600 (+)NCBI
EDNRA
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4147,480,917 - 147,544,954 (+)EnsemblGRCh38hg38GRCh38
GRCh384147,481,097 - 147,544,954 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374148,402,069 - 148,466,106 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364148,621,575 - 148,685,555 (+)NCBINCBI36hg18NCBI36
Build 344148,759,734 - 148,823,710NCBI
Celera4145,723,204 - 145,787,202 (+)NCBI
Cytogenetic Map4q31.22-q31.23NCBI
HuRef4144,129,326 - 144,193,179 (+)NCBIHuRef
CHM1_14148,380,418 - 148,444,465 (+)NCBICHM1_1
Ednra
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39878,389,658 - 78,451,081 (-)NCBI
GRCm38877,663,029 - 77,724,452 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl877,663,031 - 77,724,464 (-)EnsemblGRCm38mm10GRCm38
MGSCv37880,186,928 - 80,248,351 (-)NCBIGRCm37mm9NCBIm37
MGSCv36880,559,140 - 80,620,420 (-)NCBImm8
Celera881,946,457 - 82,007,225 (-)NCBICelera
Cytogenetic Map8C1NCBI
Ednra
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01933,928,356 - 33,991,703 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1933,928,356 - 33,991,703 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01944,812,252 - 44,874,904 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41932,042,366 - 32,108,153 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11932,051,058 - 32,110,066 (+)NCBI
Celera1929,719,589 - 29,778,843 (+)NCBICelera
Cytogenetic Map19q11NCBI
Ednra
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554283,062,303 - 3,114,761 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554283,062,303 - 3,114,761 (+)NCBIChiLan1.0ChiLan1.0
EDNRA
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1545,823,560 - 45,876,463 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11545,823,472 - 45,878,527 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Ednra
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365351,950,117 - 2,005,786 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
EDNRA
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl881,209,327 - 81,276,853 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1881,210,750 - 81,279,053 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2886,293,177 - 86,319,721 (-)NCBISscrofa10.2Sscrofa10.2susScr3
EDNRA
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl793,985,797 - 94,042,296 (+)Ensembl
ChlSab1.1793,980,983 - 94,043,863 (+)NCBI
Ednra
(Heterocephalus glaber - naked mole-rat)
No map positions available.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_024928491   ⟹   XP_024784259
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.14151,476,353 - 151,518,351 (+)NCBI
Mhudiblu_PPA_v04139,815,448 - 139,863,498 (+)NCBI
Sequence:
RefSeq Acc Id: XM_034959222   ⟹   XP_034815113
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v04139,815,336 - 139,879,600 (+)NCBI
Protein Sequences
Protein RefSeqs XP_024784259 (Get FASTA)   NCBI Sequence Viewer  
  XP_034815113 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_024784259   ⟸   XM_024928491
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: XP_034815113   ⟸   XM_034959222
- Peptide Label: isoform X1
Protein Domains
G_PROTEIN_RECEP_F1_2


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000037609 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000029164 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000052013 UniProtKB/TrEMBL
InterPro Endthln_rcpt UniProtKB/TrEMBL
  ETA_rcpt UniProtKB/TrEMBL
  GPCR_Rhodpsn UniProtKB/TrEMBL
  GPCR_Rhodpsn_7TM UniProtKB/TrEMBL
KEGG Report pps:100968812 UniProtKB/TrEMBL
NCBI Gene EDNRA ENTREZGENE
Pfam 7tm_1 UniProtKB/TrEMBL
PRINTS ENDOTHELINAR UniProtKB/TrEMBL
  ENDOTHELINR UniProtKB/TrEMBL
  GPCRRHODOPSN UniProtKB/TrEMBL
PROSITE G_PROTEIN_RECEP_F1_1 UniProtKB/TrEMBL
  G_PROTEIN_RECEP_F1_2 UniProtKB/TrEMBL
UniProt A0A2R9BHM9_PANPA UniProtKB/TrEMBL

 



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.