CYP2E1 (cytochrome P450 family 2 subfamily E member 1) - Chinchilla Research Resource Database
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Gene: CYP2E1 (cytochrome P450 family 2 subfamily E member 1) Pan paniscus
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Symbol: CYP2E1
Name: cytochrome P450 family 2 subfamily E member 1
CRRD ID: 11731615
Description: ENCODES a protein that exhibits 4-nitrophenol 2-monooxygenase activity (ortholog); enzyme binding (ortholog); heme binding (ortholog); INVOLVED IN 4-nitrophenol metabolic process (ortholog); drug metabolic process (ortholog); heterocycle metabolic process (ortholog); PARTICIPATES IN acetylsalicylic acid pharmacodynamics pathway; antipyrine drug pathway; arachidonic acid metabolic pathway; ASSOCIATED WITH acoustic neuroma (ortholog); acute kidney failure (ortholog); acute lymphoblastic leukemia (ortholog); FOUND IN endoplasmic reticulum (ortholog); endoplasmic reticulum membrane (ortholog); Golgi membrane (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: cytochrome P450 2E1; LOC100981327
Orthologs:
Homo sapiens (human) : CYP2E1 (cytochrome P450 family 2 subfamily E member 1)  HGNC  Alliance
Mus musculus (house mouse) : Cyp2e1 (cytochrome P450, family 2, subfamily e, polypeptide 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cyp2e1 (cytochrome P450, family 2, subfamily e, polypeptide 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102026028 (cytochrome P450 2E1)
Canis lupus familiaris (dog) : CYP2E1 (cytochrome P450 family 2 subfamily E member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101973029 (cytochrome P450 2E1)
Sus scrofa (pig) : CYP2E1 (cytochrome P450, family 2, subfamily E, polypeptide 1)
Chlorocebus sabaeus (African green monkey) : CYP2E1 (cytochrome P450 family 2 subfamily E member 1)
Heterocephalus glaber (naked mole-rat) : LOC101722366 (cytochrome P450 2E1)
more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.110134,839,025 - 134,852,053 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10134,839,025 - 134,852,719 (+)Ensemblpanpan1.1panPan2


Disease Annotations     Click to see Annotation Detail View
acoustic neuroma  (ISO)
acute kidney failure  (ISO)
acute lymphoblastic leukemia  (ISO)
adenocarcinoma  (ISO)
alcohol use disorder  (ISO)
Alcoholic Fatty Liver  (ISO)
alcoholic liver cirrhosis  (ISO)
Alcoholic Liver Diseases  (ISO)
amenorrhea  (ISO)
asbestosis  (ISO)
asthma  (ISO)
Binge Drinking  (ISO)
Cardiomegaly  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
Chronic Bronchitis  (ISO)
chronic obstructive pulmonary disease  (ISO)
colon cancer  (ISO)
colorectal cancer  (ISO)
Diabetes Mellitus, Experimental  (ISO)
Drug Eruptions  (ISO)
drug-induced hepatitis  (ISO)
Drug-Related Side Effects and Adverse Reactions  (ISO)
Experimental Liver Neoplasms  (ISO)
extrinsic allergic alveolitis  (ISO)
familial hyperlipidemia  (ISO)
fatty liver disease  (ISO)
hepatocellular adenoma  (ISO)
hepatocellular carcinoma  (ISO)
Human Viral Hepatitis  (ISO)
intrahepatic cholestasis  (ISO)
liver disease  (ISO)
Liver Injury  (ISO)
Liver Neoplasms  (ISO)
lung disease  (ISO)
Lung Neoplasms  (ISO)
lung non-small cell carcinoma  (ISO)
malignant glioma  (ISO)
mental depression  (ISO)
Micronuclei, Chromosome-Defective  (ISO)
middle cerebral artery infarction  (ISO)
morbid obesity  (ISO)
nasopharynx carcinoma  (ISO)
Necrosis  (ISO)
Neoplasm Invasiveness  (ISO)
non-alcoholic fatty liver disease  (ISO)
non-Hodgkin lymphoma  (ISO)
obesity  (ISO)
oral cavity cancer  (ISO)
oral squamous cell carcinoma  (ISO)
Parkinson's disease  (ISO)
Patent Ductus Venosus  (ISO)
pneumonia  (ISO)
Prostatic Neoplasms  (ISO)
Reperfusion Injury  (ISO)
Sepsis  (ISO)
stomach cancer  (ISO)
Testicular Injury  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)


Molecular Pathway Annotations     Click to see Annotation Detail View
acetylsalicylic acid pharmacodynamics pathway  (ISO)
antipyrine drug pathway  (ISO)
arachidonic acid metabolic pathway  (ISO)
caffeine pharmacokinetics pathway  (ISO)
celecoxib pharmacodynamics pathway  (ISO)
diclofenac pharmacodynamics pathway  (ISO)
diflunisal pharmacodynamics pathway  (ISO)
disulfiram pharmacodynamics pathway  (ISO)
etodolac pharmacodynamics pathway  (ISO)
felbamate pharmacokinetics pathway  (ISO)
fenoprofen pharmacodynamics pathway  (ISO)
flurbiprofen pharmacodynamics pathway  (ISO)
ibuprofen pharmacodynamics pathway  (ISO)
indometacin pharmacodynamics pathway  (ISO)
indometacin pharmacodynamics pathway  (ISO)
ketoprofen pharmacodynamics pathway  (ISO)
ketorolac pharmacodynamics pathway  (ISO)
leukotriene C4 synthase deficiency pathway  (ISO)
lornoxicam pharmacodynamics pathway  (ISO)
magnesium salicylate pharmacodynamics pathway  (ISO)
mefenamic acid pharmacodynamics pathway  (ISO)
meloxicam pharmacodynamics pathway  (ISO)
nabumetone pharmacodynamics pathway  (ISO)
naproxen pharmacodynamics pathway  (ISO)
paracetamol drug pathway  (ISO)
paracetamol pharmacokinetics pathway  (ISO)
paracetamol response pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
piroxicam pharmacodynamics pathway  (ISO)
salicylic acid pharmacodynamics pathway  (ISO)
sodium salicylate pharmacodynamics pathway  (ISO)
sulindac pharmacodynamics pathway  (ISO)
tenoxicam pharmacodynamics pathway  (ISO)
tiaprofenic acid pharmacodynamics pathway  (ISO)
tolmetin pharmacodynamics pathway  (ISO)
valdecoxib pharmacodynamics pathway  (ISO)

References

Genomics

Comparative Map Data
CYP2E1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.110134,839,025 - 134,852,053 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl10134,839,025 - 134,852,719 (+)Ensemblpanpan1.1panPan2
CYP2E1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl10133,520,406 - 133,561,220 (+)EnsemblGRCh38hg38GRCh38
GRCh3810133,527,363 - 133,539,123 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh3710135,340,300 - 135,352,627 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3610135,190,857 - 135,202,610 (+)NCBINCBI36hg18NCBI36
Build 3410135,229,747 - 135,241,501NCBI
Celera10128,168,529 - 128,180,282 (-)NCBI
Cytogenetic Map10q26.3NCBI
HuRef10128,882,691 - 128,894,624 (+)NCBIHuRef
CHM1_110135,620,490 - 135,632,188 (+)NCBICHM1_1
Cyp2e1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm397140,343,732 - 140,354,903 (+)NCBI
GRCm387140,763,819 - 140,774,990 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl7140,763,739 - 140,774,987 (+)EnsemblGRCm38mm10GRCm38
MGSCv377147,949,731 - 147,960,880 (+)NCBIGRCm37mm9NCBIm37
MGSCv367140,615,152 - 140,626,301 (+)NCBImm8
Celera7140,556,087 - 140,567,236 (+)NCBICelera
Cytogenetic Map7F4NCBI
cM Map785.94NCBI
Cyp2e1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01213,511,892 - 213,522,195 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1213,511,874 - 213,535,542 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01220,405,975 - 220,416,727 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41200,918,521 - 200,928,919 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11201,068,525 - 201,078,911 (+)NCBI
Celera1193,484,404 - 193,494,772 (+)NCBICelera
Cytogenetic Map1q41NCBI
LOC102026028
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555076,289,576 - 6,304,193 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555076,293,162 - 6,303,255 (-)NCBIChiLan1.0ChiLan1.0
CYP2E1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2841,035,025 - 41,122,754 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12841,079,164 - 41,089,188 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
LOC101973029
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493648619,691,822 - 19,702,684 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CYP2E1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl14141,690,426 - 141,736,818 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.114141,690,737 - 141,703,078 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.214153,478,051 - 153,490,404 (+)NCBISscrofa10.2Sscrofa10.2susScr3
CYP2E1
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl2653,390,089 - 53,404,211 (+)Ensembl
ChlSab1.12653,390,054 - 53,403,309 (+)NCBI
LOC101722366
(Heterocephalus glaber - naked mole-rat)
No map positions available.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_034951455 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide SSBP01000485 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000047958   ⟹   ENSPPAP00000025132
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl10134,839,025 - 134,852,053 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000047963   ⟹   ENSPPAP00000025137
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl10134,839,582 - 134,852,719 (+)Ensembl
RefSeq Acc Id: ENSPPAT00000047972   ⟹   ENSPPAP00000025146
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl10134,839,622 - 134,852,027 (+)Ensembl
RefSeq Acc Id: XM_008972424   ⟹   XP_008970672
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.110134,839,025 - 134,852,053 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_034807346 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_008970672   ⟸   XM_008972424
- Sequence:
RefSeq Acc Id: ENSPPAP00000025132   ⟸   ENSPPAT00000047958
RefSeq Acc Id: ENSPPAP00000025137   ⟸   ENSPPAT00000047963
RefSeq Acc Id: ENSPPAP00000025146   ⟸   ENSPPAT00000047972


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000035698 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000025132 UniProtKB/TrEMBL
  ENSPPAP00000025137 UniProtKB/TrEMBL
  ENSPPAP00000025146 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000047958 UniProtKB/TrEMBL
  ENSPPAT00000047963 UniProtKB/TrEMBL
  ENSPPAT00000047972 UniProtKB/TrEMBL
Gene3D-CATH 1.10.630.10 UniProtKB/TrEMBL
InterPro Cyt_P450 UniProtKB/TrEMBL
  Cyt_P450_CS UniProtKB/TrEMBL
  Cyt_P450_E_grp-I UniProtKB/TrEMBL
  Cyt_P450_E_grp-I_CYP2E-like UniProtKB/TrEMBL
  Cyt_P450_sf UniProtKB/TrEMBL
KEGG Report pps:100981327 UniProtKB/TrEMBL
NCBI Gene LOC100981327 ENTREZGENE
Pfam p450 UniProtKB/TrEMBL
PRINTS EP450I UniProtKB/TrEMBL
  EP450ICYP2E UniProtKB/TrEMBL
  P450 UniProtKB/TrEMBL
PROSITE CYTOCHROME_P450 UniProtKB/TrEMBL
Superfamily-SCOP SSF48264 UniProtKB/TrEMBL
UniProt A0A2R9B6B1_PANPA UniProtKB/TrEMBL
  A0A2R9B6B5_PANPA UniProtKB/TrEMBL
  A0A2R9B7V8_PANPA UniProtKB/TrEMBL
VGNC ID VGNC:83029 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2020-02-25 CYP2E1  cytochrome P450 family 2 subfamily E member 1  LOC100981327  cytochrome P450 2E1  Symbol and/or name change 5135510 APPROVED

 



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.