HCRT (hypocretin neuropeptide precursor) - Chinchilla Research Resource Database
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Gene: HCRT (hypocretin neuropeptide precursor) Pan paniscus
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Symbol: HCRT
Name: hypocretin neuropeptide precursor
CRRD ID: 11759550
Description: ENCODES a protein that exhibits neuropeptide hormone activity (ortholog); type 1 hypocretin receptor binding (ortholog); type 2 hypocretin receptor binding (ortholog); INVOLVED IN eating behavior (ortholog); excitatory postsynaptic potential (ortholog); negative regulation of DNA replication (ortholog); PARTICIPATES IN orexin/hypocretin signaling pathway; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 1; orexin/hypocretin signaling pathway via orexin/hypocretin receptor 2; ASSOCIATED WITH Cocaine-Related Disorders (ortholog); Guillain-Barre syndrome (ortholog); hyperglycemia (ortholog); FOUND IN cytoplasm (ortholog); perinuclear region of cytoplasm (ortholog); secretory granule (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: orexin
Orthologs:
Homo sapiens (human) : HCRT (hypocretin neuropeptide precursor)  HGNC  Alliance
Mus musculus (house mouse) : Hcrt (hypocretin)  MGI  Alliance
Rattus norvegicus (Norway rat) : Hcrt (hypocretin neuropeptide precursor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Hcrt (hypocretin neuropeptide precursor)
Canis lupus familiaris (dog) : HCRT (hypocretin neuropeptide precursor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Hcrt (hypocretin neuropeptide precursor)
Sus scrofa (pig) : HCRT (hypocretin neuropeptide precursor)
Chlorocebus sabaeus (African green monkey) : HCRT (hypocretin neuropeptide precursor)
Heterocephalus glaber (naked mole-rat) : Hcrt (hypocretin neuropeptide precursor)
more info ...
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11715,353,203 - 15,354,594 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1715,353,203 - 15,354,594 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01715,130,581 - 15,132,024 (+)NCBIMhudiblu_PPA_v0panPan3
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

References

Genomics

Comparative Map Data
HCRT
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11715,353,203 - 15,354,594 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1715,353,203 - 15,354,594 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01715,130,581 - 15,132,024 (+)NCBIMhudiblu_PPA_v0panPan3
HCRT
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1742,184,060 - 42,185,452 (-)EnsemblGRCh38hg38GRCh38
GRCh381742,184,060 - 42,185,452 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371740,336,078 - 40,337,470 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361737,589,604 - 37,590,996 (-)NCBINCBI36hg18NCBI36
Build 341737,589,603 - 37,590,996NCBI
Celera1736,990,305 - 36,991,697 (-)NCBI
Cytogenetic Map17q21.2NCBI
HuRef1736,101,194 - 36,102,586 (-)NCBIHuRef
CHM1_11740,571,806 - 40,573,198 (-)NCBICHM1_1
Hcrt
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911100,652,519 - 100,653,757 (-)NCBI
GRCm3811100,761,693 - 100,762,931 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11100,761,069 - 100,762,931 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711100,623,007 - 100,624,245 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611100,577,783 - 100,579,021 (-)NCBImm8
Celera11111,378,254 - 111,379,492 (-)NCBICelera
Cytogenetic Map11DNCBI
cM Map1163.6NCBI
Hcrt
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01088,669,216 - 88,670,430 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1088,669,214 - 88,670,430 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01088,463,386 - 88,464,600 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41089,699,633 - 89,700,847 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11089,714,002 - 89,715,214 (-)NCBI
Celera1084,405,435 - 84,406,649 (-)NCBICelera
Cytogenetic Map10q31NCBI
Hcrt
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495545116,235,819 - 16,237,457 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495545116,235,819 - 16,237,457 (-)NCBIChiLan1.0ChiLan1.0
HCRT
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl920,730,779 - 20,732,028 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1920,729,616 - 20,732,074 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Hcrt
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_00493649017,007,001 - 17,008,363 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
HCRT
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1220,581,022 - 20,589,988 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11220,588,597 - 20,589,991 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21220,877,771 - 20,880,147 (+)NCBISscrofa10.2Sscrofa10.2susScr3
HCRT
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl1664,084,070 - 64,085,292 (+)Ensembl
ChlSab1.11664,083,199 - 64,085,393 (+)NCBI
Hcrt
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247951,744,782 - 1,747,360 (+)NCBI


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts XM_003813875 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide SSBP01000305 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSPPAT00000036181   ⟹   ENSPPAP00000013509
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.1 Ensembl1715,353,203 - 15,354,594 (+)Ensembl
RefSeq Acc Id: XM_003813875   ⟹   XP_003813923
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
PanPan1.11715,353,203 - 15,354,594 (+)NCBI
Mhudiblu_PPA_v01715,130,581 - 15,132,024 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_003813923 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_003813923   ⟸   XM_003813875
- Sequence:
RefSeq Acc Id: ENSPPAP00000013509   ⟸   ENSPPAT00000036181


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000029937 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000013509 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000036181 UniProtKB/TrEMBL
InterPro Orexin UniProtKB/TrEMBL
KEGG Report pps:100987436 UniProtKB/TrEMBL
NCBI Gene HCRT ENTREZGENE
PANTHER PTHR15173 UniProtKB/TrEMBL
Pfam Orexin UniProtKB/TrEMBL
PIRSF Orexin UniProtKB/TrEMBL
PRINTS OREXINPP UniProtKB/TrEMBL
UniProt A0A2R9A8A9_PANPA UniProtKB/TrEMBL