CACNA2D2 (calcium voltage-gated channel auxiliary subunit alpha2delta 2) - Chinchilla Research Resource Database
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Gene: CACNA2D2 (calcium voltage-gated channel auxiliary subunit alpha2delta 2) Pan paniscus
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Symbol: CACNA2D2
Name: calcium voltage-gated channel auxiliary subunit alpha2delta 2
CRRD ID: 11759614
Description: ENCODES a protein that exhibits voltage-gated calcium channel activity (ortholog); INVOLVED IN calcium ion transport (ortholog); muscle fiber development (ortholog); neuromuscular junction development (ortholog); PARTICIPATES IN acebutolol pharmacodynamics pathway; adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway; alfentanil pharmacodynamics pathway; ASSOCIATED WITH Ataxia (ortholog); Cardiac Arrhythmias (ortholog); Cerebellar Atrophy with Seizures and Variable Developmental Delay (ortholog); FOUND IN voltage-gated calcium channel complex (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: voltage-dependent calcium channel subunit alpha-2/delta-2
Orthologs:
Latest Assembly: Mhudiblu_PPA_v0 - Bonobo Mhudiblu_PPA_v0 Assembly
Position:
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1351,524,200 - 51,638,249 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl351,526,075 - 51,640,406 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0350,288,926 - 50,430,152 (-)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
acebutolol pharmacodynamics pathway  (ISO)
adrenergic beta receptor agonist and beta-blocker pharmacodynamics pathway  (ISO)
alfentanil pharmacodynamics pathway  (ISO)
amiodarone pharmacodynamics pathway  (ISO)
amlodipine pharmacodynamics pathway  (ISO)
atenolol pharmacodynamics pathway  (ISO)
betaxolol pharmacodynamics pathway  (ISO)
bisoprolol pharmacodynamics pathway  (ISO)
bupivacaine pharmacodynamics pathway  (ISO)
bupranolol drug pathway  (ISO)
bupranolol pharmacodynamics pathway  (ISO)
buprenorphine pharmacodynamics pathway  (ISO)
carvedilol pharmacodynamics pathway  (ISO)
chloroprocaine pharmacodynamics pathway  (ISO)
citalopram pharmacodynamics pathway  (ISO)
cocaine pharmacodynamics pathway  (ISO)
codeine and morphine pharmacodynamics pathway  (ISO)
desipramine pharmacodynamics pathway  (ISO)
diltiazem pharmacodynamics pathway  (ISO)
diphenoxylate pharmacodynamics pathway  (ISO)
disopyramide pharmacodynamics pathway  (ISO)
dobutamine pharmacodynamics pathway  (ISO)
escitalopram pharmacodynamics pathway  (ISO)
esmolol pharmacodynamics pathway  (ISO)
ethylmorphine pharmacodynamics pathway  (ISO)
felodipine pharmacokinetics pathway  (ISO)
fentanyl pharmacodynamics pathway  (ISO)
flecainde pharmacodynamics pathway  (ISO)
fluoxetine pharmacodynamics pathway  (ISO)
fosphenytoin pharmacodynamics pathway  (ISO)
gliclazide pharmacodynamics pathway  (ISO)
glyburide pharmacodynamics pathway  (ISO)
heroin pharmacodynamics pathway  (ISO)
hydrocodone pharmacodynamics pathway  (ISO)
hydromorphone pharmacodynamics pathway  (ISO)
ibutilide pharmacodynamics pathway  (ISO)
imipramine pharmacodynamics pathway  (ISO)
isoprenaline pharmacodynamics pathway  (ISO)
isradipine pharmacodynamics pathway  (ISO)
levacetylmethadol pharmacodynamics pathway  (ISO)
levobunolol pharmacodynamics pathway  (ISO)
levobupivacaine phgarmacodynamics pathway  (ISO)
levorphanol pharmacodynamics pathway  (ISO)
lidocaine pharmacodynamics pathway  (ISO)
mepivacaine pharmacodynamics pathway  (ISO)
methadone pharmacodynamics pathway  (ISO)
metoprolol pharmacodynamics pathway  (ISO)
mexiletine pharmacodynamics pathway  (ISO)
nadolol pharmacodynamics pathway  (ISO)
nalbuphine pharmacodynamics pathway  (ISO)
naloxone pharmacodynamics pathway  (ISO)
naltrexone pharmacodynamics pathway  (ISO)
nebivolol pharmacodynamics pathway  (ISO)
nicotine pharmacodynamics pathway  (ISO)
nifedipine pharmacodynamics pathway  (ISO)
nimodipine pharmacodynamics pathway  (ISO)
nisoldipine pharmacodynamics pathway  (ISO)
nitrendipine pharmacodynamics pathway  (ISO)
oxybuprocaine pharmacodynamics pathway  (ISO)
oxycodone pharmacodynamics pathway  (ISO)
oxymorphone pharmacodynamics pathway  (ISO)
penbutolol pharmacodynamics pathway  (ISO)
pentazocine pharmacodynamics pathway  (ISO)
phenytoin pharmacodynamics pathway  (ISO)
pindolol pharmacodynamics pathway  (ISO)
potassium channel inhibitors pharmacodynamics pathway  (ISO)
prilocaine pharmacodynamics pathway  (ISO)
procainamide pharmacodynamics pathway  (ISO)
procaine pharmacodynamics pathway  (ISO)
propranolol pharmacodynamics pathway  (ISO)
quinidine pharmacodynamics pathway  (ISO)
remifentanil pharmacodynamics pathway  (ISO)
ropivacaine pharmacodynamics pathway  (ISO)
sotalol pharmacodynamics pathway  (ISO)
timolol pharmacodynamics pathway  (ISO)
tramadol pharmacodynamics pathway  (ISO)
verapamil pharmacodynamics pathway  (ISO)

References

Genomics

Comparative Map Data
CACNA2D2
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1351,524,200 - 51,638,249 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl351,526,075 - 51,640,406 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0350,288,926 - 50,430,152 (-)NCBI
CACNA2D2
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl350,362,799 - 50,504,244 (-)EnsemblGRCh38hg38GRCh38
GRCh38350,362,613 - 50,504,244 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37350,400,230 - 50,540,892 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36350,375,234 - 50,515,896 (-)NCBINCBI36hg18NCBI36
Build 34350,375,233 - 50,515,896NCBI
Celera350,373,061 - 50,513,724 (-)NCBI
Cytogenetic Map3p21.31NCBI
HuRef350,455,831 - 50,596,932 (-)NCBIHuRef
CHM1_1350,352,319 - 50,493,905 (-)NCBICHM1_1
Cacna2d2
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm399107,276,948 - 107,406,545 (+)NCBI
GRCm389107,399,733 - 107,529,346 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl9107,399,612 - 107,529,343 (+)EnsemblGRCm38mm10GRCm38
MGSCv379107,302,211 - 107,431,674 (+)NCBIGRCm37mm9NCBIm37
MGSCv369107,257,713 - 107,387,159 (+)NCBImm8
Celera9107,007,997 - 107,138,095 (+)NCBICelera
Cytogenetic Map9F1NCBI
cM Map958.02NCBI
Cacna2d2
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.08116,154,661 - 116,285,643 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl8116,154,736 - 116,284,985 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.08115,510,729 - 115,641,903 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.48112,643,409 - 112,775,460 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.18112,662,863 - 112,794,915 (+)NCBI
Celera8107,381,970 - 107,508,046 (+)NCBICelera
Cytogenetic Map8q32NCBI
Cacna2d2
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555322,163,529 - 2,283,508 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555322,163,529 - 2,283,509 (-)NCBIChiLan1.0ChiLan1.0
CACNA2D2
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl2038,883,530 - 38,993,273 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.12038,859,047 - 38,995,239 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
Cacna2d2
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365291,889,811 - 2,023,710 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
CACNA2D2
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1332,845,115 - 32,988,774 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11332,845,110 - 32,988,851 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21336,023,325 - 36,167,052 (-)NCBISscrofa10.2Sscrofa10.2susScr3
CACNA2D2
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl2211,749,727 - 11,890,924 (-)Ensembl
ChlSab1.12211,751,026 - 11,891,407 (-)NCBI
Cacna2d2
(Heterocephalus glaber - naked mole-rat)
No map positions available.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: XM_034956523   ⟹   XP_034812414
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0350,288,926 - 50,430,152 (-)NCBI
RefSeq Acc Id: XM_034956524   ⟹   XP_034812415
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0350,288,926 - 50,429,879 (-)NCBI
RefSeq Acc Id: XM_034956525   ⟹   XP_034812416
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0350,288,926 - 50,429,879 (-)NCBI
RefSeq Acc Id: XM_034956527   ⟹   XP_034812418
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0350,288,926 - 50,430,091 (-)NCBI
RefSeq Acc Id: XM_034956528   ⟹   XP_034812419
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0350,288,926 - 50,429,879 (-)NCBI
RefSeq Acc Id: XM_034956529   ⟹   XP_034812420
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0350,288,926 - 50,429,879 (-)NCBI
RefSeq Acc Id: XM_034956530   ⟹   XP_034812421
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0350,288,926 - 50,429,879 (-)NCBI
RefSeq Acc Id: XM_034956531   ⟹   XP_034812422
RefSeq Status:
Type: CODING
Position:
Bonobo AssemblyChrPosition (strand)Source
Mhudiblu_PPA_v0350,288,926 - 50,430,091 (-)NCBI
Reference Sequences
RefSeq Acc Id: XP_034812414   ⟸   XM_034956523
- Peptide Label: isoform X1
RefSeq Acc Id: XP_034812422   ⟸   XM_034956531
- Peptide Label: isoform X8
RefSeq Acc Id: XP_034812418   ⟸   XM_034956527
- Peptide Label: isoform X4
RefSeq Acc Id: XP_034812420   ⟸   XM_034956529
- Peptide Label: isoform X6
RefSeq Acc Id: XP_034812421   ⟸   XM_034956530
- Peptide Label: isoform X7
RefSeq Acc Id: XP_034812419   ⟸   XM_034956528
- Peptide Label: isoform X5
RefSeq Acc Id: XP_034812415   ⟸   XM_034956524
- Peptide Label: isoform X2
RefSeq Acc Id: XP_034812416   ⟸   XM_034956525
- Peptide Label: isoform X3
Protein Domains
VWFA


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSPPAG00000039612 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSPPAP00000033612 UniProtKB/TrEMBL
  ENSPPAP00000033631 UniProtKB/TrEMBL
Ensembl Transcript ENSPPAT00000056488 UniProtKB/TrEMBL
  ENSPPAT00000056507 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.410 UniProtKB/TrEMBL
InterPro VDCC_a2/dsu UniProtKB/TrEMBL
  VWA_N UniProtKB/TrEMBL
  VWF_A UniProtKB/TrEMBL
  vWFA_dom_sf UniProtKB/TrEMBL
NCBI Gene CACNA2D2 ENTREZGENE
Pfam VGCC_alpha2 UniProtKB/TrEMBL
  VWA UniProtKB/TrEMBL
  VWA_N UniProtKB/TrEMBL
PROSITE VWFA UniProtKB/TrEMBL
SMART VWA UniProtKB/TrEMBL
Superfamily-SCOP SSF53300 UniProtKB/TrEMBL
UniProt A0A2R9BVA5_PANPA UniProtKB/TrEMBL
  A0A2R9BVZ5_PANPA UniProtKB/TrEMBL

 



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.