MCM4 (minichromosome maintenance complex component 4) - Chinchilla Research Resource Database
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Gene: MCM4 (minichromosome maintenance complex component 4) Canis lupus familiaris
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Symbol: MCM4
Name: minichromosome maintenance complex component 4
CRRD ID: 12209120
Description: ENCODES a protein that exhibits DNA helicase activity (ortholog); INVOLVED IN DNA duplex unwinding (inferred); DNA replication initiation (inferred); ASSOCIATED WITH Developmental Disabilities (ortholog); immunodeficiency 54 (ortholog); microcephaly (ortholog); FOUND IN MCM complex (inferred); nucleoplasm (inferred); nucleus (inferred)
Type: protein-coding
RefSeq Status: MODEL
Also known as: DNA replication licensing factor MCM4
Orthologs:
Homo sapiens (human) : MCM4 (minichromosome maintenance complex component 4)  HGNC  Alliance
Mus musculus (house mouse) : Mcm4 (minichromosome maintenance complex component 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Mcm4 (minichromosome maintenance complex component 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mcm4 (minichromosome maintenance complex component 4)
Pan paniscus (bonobo/pygmy chimpanzee) : MCM4 (minichromosome maintenance complex component 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mcm4 (minichromosome maintenance complex component 4)
Sus scrofa (pig) : MCM4 (minichromosome maintenance complex component 4)
Chlorocebus sabaeus (African green monkey) : MCM4 (minichromosome maintenance complex component 4)
Heterocephalus glaber (naked mole-rat) : Mcm4 (minichromosome maintenance complex component 4)
more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl29244,656 - 260,991 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.129244,634 - 261,154 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component
MCM complex  (IBA,IEA)
nucleoplasm  (IEA)
nucleus  (IBA,IEA)

Molecular Function

References

Genomics

Comparative Map Data
MCM4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl29244,656 - 260,991 (+)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.129244,634 - 261,154 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
MCM4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl847,960,185 - 47,978,160 (+)EnsemblGRCh38hg38GRCh38
GRCh38847,960,941 - 47,978,160 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37848,872,763 - 48,890,720 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36849,036,047 - 49,052,621 (+)NCBINCBI36hg18NCBI36
Build 34849,036,046 - 49,052,621NCBI
Celera844,858,902 - 44,875,475 (+)NCBI
Cytogenetic Map8q11.21NCBI
HuRef844,335,726 - 44,353,327 (+)NCBIHuRef
CHM1_1848,925,125 - 48,943,082 (+)NCBICHM1_1
Mcm4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391615,441,761 - 15,455,264 (-)NCBI
GRCm381615,623,897 - 15,637,400 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1615,623,897 - 15,637,400 (-)EnsemblGRCm38mm10GRCm38
MGSCv371615,623,990 - 15,637,493 (-)NCBIGRCm37mm9NCBIm37
MGSCv361615,537,681 - 15,550,934 (-)NCBImm8
Celera1616,200,304 - 16,213,825 (-)NCBICelera
Cytogenetic Map16A2NCBI
cM Map1610.09NCBI
Mcm4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01189,511,191 - 89,524,892 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1189,511,191 - 89,524,892 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01192,565,514 - 92,579,215 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41187,169,742 - 87,183,443 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11187,215,525 - 87,215,708 (+)NCBI
Celera1183,998,817 - 84,012,516 (+)NCBICelera
Cytogenetic Map11q23NCBI
Mcm4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554547,891,456 - 7,908,462 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554547,891,646 - 7,908,240 (+)NCBIChiLan1.0ChiLan1.0
MCM4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1841,779,624 - 41,794,996 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl841,778,247 - 41,794,783 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0844,387,529 - 44,404,773 (+)NCBIMhudiblu_PPA_v0panPan3
Mcm4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365904,705,028 - 4,722,320 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MCM4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl479,674,737 - 79,687,307 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1479,674,737 - 79,686,964 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2487,134,029 - 87,142,341 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MCM4
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl844,120,301 - 44,138,193 (+)Ensembl
ChlSab1.1844,120,291 - 44,136,625 (+)NCBI
Mcm4
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247357,516,510 - 7,533,789 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 3 10 6 6 5 5
Low 2 5 12 6 6 6 7 8 5 6
Below cutoff

Sequence

Nucleotide Sequences
RefSeq Transcripts XM_535063 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AAEX03015747 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSCAFT00000010664   ⟹   ENSCAFP00000009885
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl29244,656 - 260,991 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000067077   ⟹   ENSCAFP00000058582
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl29244,656 - 260,991 (+)Ensembl
RefSeq Acc Id: ENSCAFT00000089452   ⟹   ENSCAFP00000064711
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl29244,656 - 260,991 (+)Ensembl
RefSeq Acc Id: XM_535063   ⟹   XP_535063
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.129244,634 - 261,154 (+)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_535063 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_535063   ⟸   XM_535063
- UniProtKB: F6V1U9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSCAFP00000009885   ⟸   ENSCAFT00000010664
RefSeq Acc Id: ENSCAFP00000058582   ⟸   ENSCAFT00000067077
RefSeq Acc Id: ENSCAFP00000064711   ⟸   ENSCAFT00000089452
Protein Domains
MCM


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000006598 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000009885 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFP00000058582 UniProtKB/TrEMBL
  ENSCAFP00000064711 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000010664 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFT00000067077 UniProtKB/TrEMBL
  ENSCAFT00000089452 UniProtKB/TrEMBL
InterPro MCM UniProtKB/TrEMBL
  MCM_4 UniProtKB/TrEMBL
  MCM_CS UniProtKB/TrEMBL
  MCM_dom UniProtKB/TrEMBL
  MCM_lid UniProtKB/TrEMBL
  MCM_N UniProtKB/TrEMBL
  MCM_OB UniProtKB/TrEMBL
  NA-bd_OB-fold UniProtKB/TrEMBL
  P-loop_NTPase UniProtKB/TrEMBL
KEGG Report cfa:477871 UniProtKB/TrEMBL
NCBI Gene MCM4 ENTREZGENE
PANTHER PTHR11630 UniProtKB/TrEMBL
  PTHR11630:SF66 UniProtKB/TrEMBL
Pfam MCM UniProtKB/TrEMBL
  MCM_lid UniProtKB/TrEMBL
  MCM_N UniProtKB/TrEMBL
  MCM_OB UniProtKB/TrEMBL
PRINTS MCMFAMILY UniProtKB/TrEMBL
  MCMPROTEIN4 UniProtKB/TrEMBL
PROSITE MCM_1 UniProtKB/TrEMBL
  MCM_2 UniProtKB/TrEMBL
SMART MCM UniProtKB/TrEMBL
Superfamily-SCOP SSF50249 UniProtKB/TrEMBL
  SSF52540 UniProtKB/TrEMBL
UniProt A0A5F4CW69_CANLF UniProtKB/TrEMBL
  A0A5F4DE45_CANLF UniProtKB/TrEMBL
  F6V1U9 ENTREZGENE, UniProtKB/TrEMBL
VGNC ID VGNC:43084 ENTREZGENE