PHF8 (PHD finger protein 8) - Chinchilla Research Resource Database
Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: PHF8 (PHD finger protein 8) Canis lupus familiaris
Analyze
Symbol: PHF8
Name: PHD finger protein 8
CRRD ID: 12225227
Description: ENCODES a protein that exhibits 2-oxoglutarate-dependent dioxygenase activity (ortholog); chromatin binding (ortholog); histone demethylase activity (ortholog); INVOLVED IN G1/S transition of mitotic cell cycle (ortholog); histone H3-K27 demethylation (ortholog); histone H3-K36 demethylation (ortholog); PARTICIPATES IN histone modification pathway; ASSOCIATED WITH autistic disorder (ortholog); epilepsy (ortholog); genetic disease (ortholog); FOUND IN nuclear membrane (ortholog); nucleolus (ortholog); nucleoplasm (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: histone lysine demethylase PHF8
Orthologs:
Homo sapiens (human) : PHF8 (PHD finger protein 8)  HGNC  Alliance
Mus musculus (house mouse) : Phf8 (PHD finger protein 8)  MGI  Alliance
Rattus norvegicus (Norway rat) : Phf8 (PHD finger protein 8)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Phf8 (PHD finger protein 8)
Pan paniscus (bonobo/pygmy chimpanzee) : PHF8 (PHD finger protein 8)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Phf8 (PHD finger protein 8)
Sus scrofa (pig) : PHF8 (PHD finger protein 8)
Chlorocebus sabaeus (African green monkey) : PHF8 (PHD finger protein 8)
Heterocephalus glaber (naked mole-rat) : Phf8 (PHD finger protein 8)
more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 EnsemblX45,571,840 - 46,081,994 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1X45,635,204 - 45,741,850 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
PHF8
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 EnsemblX45,571,840 - 46,081,994 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1X45,635,204 - 45,741,850 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
PHF8
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX53,936,676 - 54,048,958 (-)EnsemblGRCh38hg38GRCh38
GRCh38X53,936,680 - 54,048,935 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X53,963,113 - 54,075,368 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X53,979,838 - 54,087,036 (-)NCBINCBI36hg18NCBI36
Build 34X53,846,135 - 53,953,332NCBI
CeleraX57,794,656 - 57,902,802 (-)NCBI
Cytogenetic MapXp11.22NCBI
HuRefX51,017,153 - 51,124,050 (-)NCBIHuRef
CHM1_1X53,954,083 - 54,062,605 (-)NCBICHM1_1
Phf8
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X150,303,621 - 150,416,855 (+)NCBI
GRCm38X151,520,641 - 151,633,859 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX151,520,672 - 151,633,859 (+)EnsemblGRCm38mm10GRCm38
MGSCv37X147,955,215 - 148,068,400 (+)NCBIGRCm37mm9NCBIm37
MGSCv36X146,861,897 - 146,966,549 (+)NCBImm8
CeleraX132,791,679 - 132,892,823 (-)NCBICelera
Cytogenetic MapXF3NCBI
Phf8
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0X21,063,487 - 21,168,750 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX21,063,562 - 21,168,750 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.0X22,281,640 - 22,387,057 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X40,869,942 - 40,970,244 (+)NCBIRGSC3.4rn4RGSC3.4
CeleraX20,777,198 - 20,875,387 (+)NCBICelera
Cytogenetic MapXq12NCBI
Phf8
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554751,105,619 - 1,230,756 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049554751,105,619 - 1,230,758 (-)NCBIChiLan1.0ChiLan1.0
PHF8
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X54,250,970 - 54,355,278 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX54,250,970 - 54,355,913 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X46,144,815 - 46,250,594 (-)NCBI
Phf8
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_004936751850,630 - 935,382 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
PHF8
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX46,648,165 - 46,759,248 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X46,648,164 - 46,761,192 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X52,130,299 - 52,307,327 (-)NCBISscrofa10.2Sscrofa10.2susScr3
PHF8
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 EnsemblX50,058,273 - 50,172,086 (-)Ensembl
ChlSab1.1X50,058,687 - 50,172,827 (-)NCBI
Phf8
(Heterocephalus glaber - naked mole-rat)
No map positions available.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 15 10 9
Low 5 5 7 6 6 6 6 6 2 8 1 6
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: XM_005641388   ⟹   XP_005641445
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1X45,635,204 - 45,741,848 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005641389   ⟹   XP_005641446
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1X45,635,204 - 45,741,848 (-)NCBI
Sequence:
RefSeq Acc Id: XM_005641390   ⟹   XP_005641447
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1X45,635,204 - 45,741,847 (-)NCBI
Sequence:
RefSeq Acc Id: XM_014111751   ⟹   XP_013967226
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1X45,635,204 - 45,741,849 (-)NCBI
Sequence:
RefSeq Acc Id: XM_014111752   ⟹   XP_013967227
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1X45,635,204 - 45,741,848 (-)NCBI
Sequence:
RefSeq Acc Id: XM_014111753   ⟹   XP_013967228
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1X45,635,204 - 45,741,850 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022415601   ⟹   XP_022271309
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1X45,635,204 - 45,741,849 (-)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: XP_005641447   ⟸   XM_005641390
- Peptide Label: isoform X7
- Sequence:
RefSeq Acc Id: XP_005641446   ⟸   XM_005641389
- Peptide Label: isoform X6
- Sequence:
RefSeq Acc Id: XP_013967228   ⟸   XM_014111753
- Peptide Label: isoform X3
- Sequence:
RefSeq Acc Id: XP_013967227   ⟸   XM_014111752
- Peptide Label: isoform X2
- UniProtKB: F1P981 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_013967226   ⟸   XM_014111751
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_005641445   ⟸   XM_005641388
- Peptide Label: isoform X4
- Sequence:
RefSeq Acc Id: XP_022271309   ⟸   XM_022415601
- Peptide Label: isoform X5
- Sequence:
Protein Domains
JmjC   PHD-type   Protein kinase

Promoters
RGD ID:13689333
Promoter ID:EPDNEW_C7403
Type:single initiation site
Name:PHF8_1
Description:PHD finger protein 8
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1X45,741,838 - 45,741,898EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000016427 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000024137 UniProtKB/TrEMBL
  ENSCAFP00000024150 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFP00000041011 UniProtKB/TrEMBL
  ENSCAFP00000053443 UniProtKB/TrEMBL
  ENSCAFP00000054264 UniProtKB/TrEMBL
  ENSCAFP00000062584 UniProtKB/TrEMBL
  ENSCAFP00000065310 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000025999 UniProtKB/TrEMBL
  ENSCAFT00000026012 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFT00000047380 UniProtKB/TrEMBL
  ENSCAFT00000070215 UniProtKB/TrEMBL
  ENSCAFT00000084253 UniProtKB/TrEMBL
  ENSCAFT00000086772 UniProtKB/TrEMBL
  ENSCAFT00000088429 UniProtKB/TrEMBL
InterPro Coact_PPARg UniProtKB/TrEMBL
  Coact_PPARg-like_2 UniProtKB/TrEMBL
  JHD UniProtKB/TrEMBL
  JmjC_dom UniProtKB/TrEMBL
  Kinase-like_dom_sf UniProtKB/TrEMBL
  Kinase_OSR1/WNK_CCT UniProtKB/TrEMBL
  PIN-like_dom_sf UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/TrEMBL
  Zinc_finger_PHD-type_CS UniProtKB/TrEMBL
  Znf_FYVE_PHD UniProtKB/TrEMBL
  Znf_PHD UniProtKB/TrEMBL
  Znf_PHD-finger UniProtKB/TrEMBL
NCBI Gene PHF8 ENTREZGENE
PANTHER PTHR15976 UniProtKB/TrEMBL
  PTHR15976:SF15 UniProtKB/TrEMBL
Pfam JHD UniProtKB/TrEMBL
  JmjC UniProtKB/TrEMBL
  OSR1_C UniProtKB/TrEMBL
  PHD UniProtKB/TrEMBL
  Pkinase UniProtKB/TrEMBL
PROSITE JMJC UniProtKB/TrEMBL
  PROTEIN_KINASE_DOM UniProtKB/TrEMBL
  PROTEIN_KINASE_ST UniProtKB/TrEMBL
  ZF_PHD_1 UniProtKB/TrEMBL
  ZF_PHD_2 UniProtKB/TrEMBL
SMART JmjC UniProtKB/TrEMBL
  PHD UniProtKB/TrEMBL
  S_TKc UniProtKB/TrEMBL
Superfamily-SCOP SSF56112 UniProtKB/TrEMBL
  SSF57903 UniProtKB/TrEMBL
  SSF88723 UniProtKB/TrEMBL
UniProt A0A5F4CGN1_CANLF UniProtKB/TrEMBL
  A0A5F4CN95_CANLF UniProtKB/TrEMBL
  A0A5F4D788_CANLF UniProtKB/TrEMBL
  A0A5F4DHJ8_CANLF UniProtKB/TrEMBL
  F1P981 ENTREZGENE, UniProtKB/TrEMBL
  F1P998_CANLF UniProtKB/TrEMBL
  J9P5T2_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:44494 ENTREZGENE

 



Contact Us |  About Us |  License CC BY 4.0 |  Legal Disclaimer |  © Medical College of Wisconsin
NHLBI Logo

RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.