G6PD (glucose-6-phosphate dehydrogenase) - Chinchilla Research Resource Database
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Gene: G6PD (glucose-6-phosphate dehydrogenase) Canis lupus familiaris
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Symbol: G6PD
Name: glucose-6-phosphate dehydrogenase
CRRD ID: 12229654
Description: ENCODES a protein that exhibits carbohydrate binding (ortholog); identical protein binding (ortholog); INVOLVED IN angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure (ortholog); angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure (ortholog); cytokine production (ortholog); PARTICIPATES IN pentose phosphate pathway; pentose phosphate pathway - oxidative phase; ribose 5-phosphate isomerase deficiency pathway; ASSOCIATED WITH acute kidney failure (ortholog); adrenoleukodystrophy (ortholog); ALAD-Deficiency Porphyria (ortholog); FOUND IN cytoplasm (ortholog); nucleus (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: glucose-6-phosphate 1-dehydrogenase
Orthologs:
Homo sapiens (human) : G6PD (glucose-6-phosphate dehydrogenase)  HGNC  Alliance
Mus musculus (house mouse) : G6pdx (glucose-6-phosphate dehydrogenase X-linked)  MGI  Alliance
Rattus norvegicus (Norway rat) : G6pd (glucose-6-phosphate dehydrogenase)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : G6pd (glucose-6-phosphate dehydrogenase)
Pan paniscus (bonobo/pygmy chimpanzee) : G6PD (glucose-6-phosphate dehydrogenase)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : G6pd (glucose-6-phosphate dehydrogenase)
Sus scrofa (pig) : G6PD (glucose-6-phosphate dehydrogenase)
Chlorocebus sabaeus (African green monkey) : G6PD (glucose-6-phosphate dehydrogenase)
Heterocephalus glaber (naked mole-rat) : G6pd (glucose-6-phosphate dehydrogenase)
more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 EnsemblX122,205,683 - 122,231,678 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1X122,217,317 - 122,231,862 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View
acute kidney failure  (ISO)
adrenoleukodystrophy  (ISO)
ALAD-Deficiency Porphyria  (ISO)
anemia  (ISO)
Angioedema Induced by ACE Inhibitors  (ISO)
autistic disorder  (ISO)
Bloch-Sulzberger syndrome  (ISO)
Brain Injuries  (ISO)
cataract  (ISO)
cerebrovascular disease  (ISO)
Chemical and Drug Induced Liver Injury  (ISO)
cholestasis  (ISO)
chronic granulomatous disease  (ISO)
congenital hemolytic anemia  (ISO)
congenital hypothyroidism  (ISO)
congenital nonspherocytic hemolytic anemia  (ISO)
contact dermatitis  (ISO)
diabetes mellitus  (ISO)
Diabetes Mellitus, Experimental  (ISO)
Diabetic Nephropathies  (ISO)
Ectodermal Dysplasia and Immunodeficiency 1  (ISO)
favism  (ISO)
Fever  (ISO)
genetic disease  (ISO)
glucosephosphate dehydrogenase deficiency  (ISO)
Hemolysis  (ISO)
hemolytic anemia  (ISO)
hepatic encephalopathy  (ISO)
hepatocellular carcinoma  (ISO)
Hypercholesterolemia  (ISO)
hyperhomocysteinemia  (ISO)
hypertension  (ISO)
Hypertriglyceridemia  (ISO)
hypomelanosis of Ito  (ISO)
immunodeficiency 33  (ISO)
Insulin Resistance  (ISO)
kidney disease  (ISO)
Liver Injury  (ISO)
malaria  (ISO)
meningioma  (ISO)
Meningioma, Somatic  (ISO)
Metabolic Syndrome  (ISO)
Multi-Infarct Dementia  (ISO)
myocardial infarction  (ISO)
myopathy  (ISO)
Neonatal Hyperbilirubinemia  (ISO)
neonatal jaundice  (ISO)
non-alcoholic fatty liver disease  (ISO)
obesity  (ISO)
osteoporosis  (ISO)
Parkinsonism with Spasticity, X-Linked  (ISO)
phagocyte bactericidal dysfunction  (ISO)
phenylketonuria  (ISO)
Plasmodium falciparum malaria  (ISO)
Pulmonary Hypertension, Hypoxia-Induced  (ISO)
renovascular hypertension  (ISO)
Reperfusion Injury  (ISO)
severe congenital encephalopathy due to MECP2 mutation  (ISO)
Testicular Injury  (ISO)
transient cerebral ischemia  (ISO)
type 1 diabetes mellitus  (ISO)
type 2 diabetes mellitus  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process

Cellular Component

Molecular Function

References

Genomics

Comparative Map Data
G6PD
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 EnsemblX122,205,683 - 122,231,678 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.1X122,217,317 - 122,231,862 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
G6PD
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 EnsemblX154,531,391 - 154,547,572 (-)EnsemblGRCh38hg38GRCh38
GRCh38X154,531,390 - 154,547,569 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X153,759,606 - 153,775,796 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X153,412,800 - 153,428,981 (-)NCBINCBI36hg18NCBI36
Build 34X153,323,309 - 153,339,173NCBI
CeleraX153,920,654 - 153,936,836 (-)NCBI
Cytogenetic MapXq28NCBI
HuRefX142,336,102 - 142,352,295 (-)NCBIHuRef
CHM1_1X153,671,374 - 153,687,570 (-)NCBICHM1_1
G6pdx
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39X73,453,089 - 73,472,486 (-)NCBI
GRCm38X74,409,483 - 74,428,880 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 EnsemblX74,409,483 - 74,429,194 (-)EnsemblGRCm38mm10GRCm38
MGSCv37X71,654,825 - 71,674,500 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X70,662,206 - 70,681,881 (-)NCBImm8
CeleraX65,663,679 - 65,683,364 (-)NCBICelera
Cytogenetic MapXA7.3NCBI
cM MapX38.0NCBI
G6pd
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0X156,274,800 - 156,293,935 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 EnsemblX156,274,800 - 156,293,926 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01152,015,532 - 152,034,676 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4X160,186,450 - 160,192,316 (+)NCBIRGSC3.4rn4RGSC3.4
Celera1135,676,941 - 135,696,556 (+)NCBICelera
Cytogenetic MapXq37NCBI
G6pd
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555801,045,294 - 1,057,083 (-)EnsemblChiLan1.0
ChiLan1.0NW_0049555801,045,294 - 1,058,129 (-)NCBIChiLan1.0ChiLan1.0
G6PD
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1X153,843,092 - 153,860,675 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 EnsemblX153,843,092 - 153,860,674 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0X143,972,798 - 143,988,960 (-)NCBI
G6pd
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049368091,269,900 - 1,285,853 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
G6PD
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 EnsemblX125,025,257 - 125,041,033 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1X125,029,147 - 125,041,040 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.2X143,553,693 - 143,556,137 (+)NCBISscrofa10.2Sscrofa10.2susScr3
G6PD
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 EnsemblX128,770,268 - 128,786,961 (-)Ensembl
ChlSab1.1X128,768,028 - 128,788,366 (-)NCBI
G6pd
(Heterocephalus glaber - naked mole-rat)
No map positions available.


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 5 22 6 6 6 6 12 10 6
Low 5 6 8
Below cutoff

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000031161   ⟹   ENSCAFP00000028993
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 EnsemblX122,212,679 - 122,231,678 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000044270   ⟹   ENSCAFP00000042382
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 EnsemblX122,216,277 - 122,231,361 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000069075   ⟹   ENSCAFP00000045522
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 EnsemblX122,205,683 - 122,231,361 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000069134   ⟹   ENSCAFP00000053614
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 EnsemblX122,205,683 - 122,231,678 (-)Ensembl
RefSeq Acc Id: XM_005642040   ⟹   XP_005642097
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1X122,217,317 - 122,231,862 (-)NCBI
Sequence:
RefSeq Acc Id: XM_538209   ⟹   XP_538209
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1X122,217,317 - 122,231,418 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005642097 (Get FASTA)   NCBI Sequence Viewer  
  XP_538209 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005642097   ⟸   XM_005642040
- Peptide Label: isoform X1
- Sequence:
RefSeq Acc Id: XP_538209   ⟸   XM_538209
- Peptide Label: isoform X2
- Sequence:
RefSeq Acc Id: ENSCAFP00000045522   ⟸   ENSCAFT00000069075
RefSeq Acc Id: ENSCAFP00000053614   ⟸   ENSCAFT00000069134
RefSeq Acc Id: ENSCAFP00000028993   ⟸   ENSCAFT00000031161
RefSeq Acc Id: ENSCAFP00000042382   ⟸   ENSCAFT00000044270
Protein Domains
G6PD_C   G6PD_N

Promoters
RGD ID:13689473
Promoter ID:EPDNEW_C7540
Type:multiple initiation site
Name:G6PD_1
Description:glucose-6-phosphate dehydrogenase
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1X122,231,335 - 122,231,395EPDNEW

Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000019598 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000028993 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFP00000042382 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFP00000045522 UniProtKB/TrEMBL
  ENSCAFP00000053614 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000031161 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFT00000044270 ENTREZGENE, UniProtKB/TrEMBL
  ENSCAFT00000069075 UniProtKB/TrEMBL
  ENSCAFT00000069134 UniProtKB/TrEMBL
InterPro G6P_DH UniProtKB/TrEMBL
  G6P_DH_AS UniProtKB/TrEMBL
  G6P_DH_C UniProtKB/TrEMBL
  G6P_DH_NAD-bd UniProtKB/TrEMBL
  NAD(P)-bd_dom_sf UniProtKB/TrEMBL
NCBI Gene G6PD ENTREZGENE
PANTHER PTHR23429 UniProtKB/TrEMBL
Pfam G6PD_C UniProtKB/TrEMBL
  G6PD_N UniProtKB/TrEMBL
PRINTS G6PDHDRGNASE UniProtKB/TrEMBL
PROSITE G6P_DEHYDROGENASE UniProtKB/TrEMBL
Superfamily-SCOP SSF51735 UniProtKB/TrEMBL
TIGRFAMs zwf UniProtKB/TrEMBL
UniProt A0A5F4BUK0_CANLF UniProtKB/TrEMBL
  A0A5F4CLC1_CANLF UniProtKB/TrEMBL
  E2R0I9_CANLF UniProtKB/TrEMBL
  J9P9E9_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:41043 ENTREZGENE

 



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.