TLR3 (toll like receptor 3) - Chinchilla Research Resource Database
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Gene: TLR3 (toll like receptor 3) Canis lupus familiaris
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Symbol: TLR3
Name: toll like receptor 3
CRRD ID: 12255166
Description: ENCODES a protein that exhibits double-stranded RNA binding (inferred); identical protein binding (inferred); transmembrane signaling receptor activity (inferred); INVOLVED IN cellular response to drug (ortholog); cellular response to exogenous dsRNA (ortholog); cellular response to interferon-beta (ortholog); PARTICIPATES IN Toll-like receptor signaling pathway; ASSOCIATED WITH Acute-On-Chronic Liver Failure (ortholog); adult respiratory distress syndrome (ortholog); Alcoholic Liver Diseases (ortholog); FOUND IN intracellular anatomical structure (ortholog)
Type: protein-coding
RefSeq Status: MODEL
Also known as: toll-like receptor 3
Orthologs:
Homo sapiens (human) : TLR3 (toll like receptor 3)  HGNC  Alliance
Mus musculus (house mouse) : Tlr3 (toll-like receptor 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tlr3 (toll-like receptor 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tlr3 (toll like receptor 3)
Pan paniscus (bonobo/pygmy chimpanzee) : TLR3 (toll like receptor 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tlr3 (toll like receptor 3)
Sus scrofa (pig) : TLR3 (toll like receptor 3)
Chlorocebus sabaeus (African green monkey) : TLR3 (toll like receptor 3)
Heterocephalus glaber (naked mole-rat) : Tlr3 (toll like receptor 3)
more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1644,550,846 - 44,653,247 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11644,617,012 - 44,633,591 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
cellular response to drug  (ISO)
cellular response to exogenous dsRNA  (ISO)
cellular response to interferon-beta  (ISO)
cellular response to interferon-gamma  (ISO)
cellular response to mechanical stimulus  (IEA)
defense response  (ISO)
defense response to virus  (IEA)
extrinsic apoptotic signaling pathway  (IEA)
I-kappaB phosphorylation  (IEA)
inflammatory response  (IEA)
innate immune response  (IEA)
male gonad development  (ISO)
microglial cell activation  (ISO)
MyD88-independent toll-like receptor signaling pathway  (IEA)
necroptotic signaling pathway  (IEA)
positive regulation of angiogenesis  (IEA)
positive regulation of apoptotic process  (ISO)
positive regulation of chemokine production  (IEA)
positive regulation of gene expression  (ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (IEA)
positive regulation of inflammatory response  (IEA)
positive regulation of interferon-alpha production  (IEA)
positive regulation of interferon-beta production  (IEA)
positive regulation of interferon-gamma production  (IEA)
positive regulation of interleukin-12 production  (IEA)
positive regulation of interleukin-6 production  (IEA)
positive regulation of interleukin-8 production  (IEA)
positive regulation of JNK cascade  (IEA)
positive regulation of NF-kappaB transcription factor activity  (IEA)
positive regulation of NIK/NF-kappaB signaling  (IEA)
positive regulation of toll-like receptor signaling pathway  (IEA)
positive regulation of transcription by RNA polymerase II  (IEA)
positive regulation of tumor necrosis factor production  (IEA)
positive regulation of type I interferon production  (ISO)
positive regulation of type III interferon production  (IEA)
regulation of dendritic cell cytokine production  (IEA)
response to dsRNA  (IBA)
response to exogenous dsRNA  (IEA)
response to virus  (ISO)
toll-like receptor 3 signaling pathway  (IEA)
toll-like receptor signaling pathway  (ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References
Additional References at PubMed
PMID:17521746   PMID:22321737  


Genomics

Comparative Map Data
TLR3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1644,550,846 - 44,653,247 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11644,617,012 - 44,633,591 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
TLR3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl4186,069,155 - 186,088,073 (+)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl4186,069,152 - 186,088,069 (+)EnsemblGRCh38hg38GRCh38
GRCh384186,069,156 - 186,088,073 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh374186,990,309 - 187,006,252 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 364187,227,303 - 187,243,246 (+)NCBINCBI36hg18NCBI36
Build 344187,365,457 - 187,381,399NCBI
Celera4184,312,848 - 184,328,791 (+)NCBI
Cytogenetic Map4q35.1NCBI
HuRef4182,742,451 - 182,758,393 (+)NCBIHuRef
CHM1_14186,966,756 - 186,982,686 (+)NCBICHM1_1
Tlr3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39845,848,702 - 45,864,112 (-)NCBI
GRCm38845,395,665 - 45,411,075 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl845,395,665 - 45,411,080 (-)EnsemblGRCm38mm10GRCm38
MGSCv37846,481,019 - 46,495,893 (-)NCBIGRCm37mm9NCBIm37
MGSCv36846,894,482 - 46,909,356 (-)NCBImm8
Celera848,083,156 - 48,098,074 (-)NCBICelera
Cytogenetic Map8B1.1NCBI
Tlr3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01650,016,466 - 50,031,011 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1650,016,857 - 50,031,214 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01649,739,814 - 49,753,968 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41650,112,910 - 50,126,371 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11650,112,984 - 50,126,440 (+)NCBI
Celera1644,813,138 - 44,826,566 (+)NCBICelera
Cytogenetic Map16q11NCBI
Tlr3
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495540322,979,120 - 23,001,467 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495540322,977,882 - 23,001,392 (-)NCBIChiLan1.0ChiLan1.0
TLR3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.14190,446,487 - 190,462,728 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl4190,446,487 - 190,462,728 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v04178,238,352 - 178,256,264 (+)NCBIMhudiblu_PPA_v0panPan3
Tlr3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365543,370,766 - 3,388,125 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
TLR3
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1546,966,040 - 47,058,734 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11546,966,262 - 46,977,774 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21553,839,254 - 53,852,671 (-)NCBISscrofa10.2Sscrofa10.2susScr3
TLR3
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl7131,991,029 - 132,016,232 (+)Ensembl
ChlSab1.17131,991,068 - 132,014,366 (+)NCBI
Tlr3
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476916,925,969 - 16,945,250 (+)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 1 1 2
Low 5 5 21 6 6 6 6 1 11 8 6
Below cutoff 5 8

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000011868   ⟹   ENSCAFP00000011004
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1644,618,598 - 44,653,247 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000038160   ⟹   ENSCAFP00000033840
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1644,550,846 - 44,569,003 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000068923   ⟹   ENSCAFP00000055057
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1644,550,846 - 44,603,706 (-)Ensembl
RefSeq Acc Id: ENSCAFT00000080550   ⟹   ENSCAFP00000044568
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1644,569,364 - 44,653,247 (-)Ensembl
RefSeq Acc Id: XM_005629968   ⟹   XP_005630025
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11644,617,012 - 44,632,575 (-)NCBI
Sequence:
RefSeq Acc Id: XM_022404183   ⟹   XP_022259891
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11644,617,012 - 44,633,591 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_005630025 (Get FASTA)   NCBI Sequence Viewer  
  XP_022259891 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein AFA51120 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_005630025   ⟸   XM_005629968
- UniProtKB: E2RIV9 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: XP_022259891   ⟸   XM_022404183
- Sequence:
RefSeq Acc Id: ENSCAFP00000055057   ⟸   ENSCAFT00000068923
RefSeq Acc Id: ENSCAFP00000011004   ⟸   ENSCAFT00000011868
RefSeq Acc Id: ENSCAFP00000033840   ⟸   ENSCAFT00000038160
RefSeq Acc Id: ENSCAFP00000044568   ⟸   ENSCAFT00000080550
Protein Domains
DUF3719   TIR


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000007406 Ensembl, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000011004 UniProtKB/TrEMBL
  ENSCAFP00000044568 UniProtKB/TrEMBL
  ENSCAFP00000055057 UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000011868 UniProtKB/TrEMBL
  ENSCAFT00000068923 UniProtKB/TrEMBL
  ENSCAFT00000080550 UniProtKB/TrEMBL
Gene3D-CATH 3.40.50.10140 UniProtKB/TrEMBL
  3.80.10.10 UniProtKB/TrEMBL
InterPro Cys-rich_flank_reg_C UniProtKB/TrEMBL
  DUF3719 UniProtKB/TrEMBL
  FAM149 UniProtKB/TrEMBL
  L_dom-like UniProtKB/TrEMBL
  Leu-rich_rpt UniProtKB/TrEMBL
  Leu-rich_rpt_typical-subtyp UniProtKB/TrEMBL
  TIR_dom UniProtKB/TrEMBL
  TLR3 UniProtKB/TrEMBL
  TLR3_TMD UniProtKB/TrEMBL
  Toll-like_receptor UniProtKB/TrEMBL
  Toll_tir_struct_dom_sf UniProtKB/TrEMBL
NCBI Gene TLR3 ENTREZGENE
PANTHER PTHR24365 UniProtKB/TrEMBL
  PTHR24365:SF524 UniProtKB/TrEMBL
  PTHR31997 UniProtKB/TrEMBL
Pfam DUF3719 UniProtKB/TrEMBL
  LRR_8 UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
  Tlr3_TMD UniProtKB/TrEMBL
PROSITE LRR UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
SMART LRR_TYP UniProtKB/TrEMBL
  LRRCT UniProtKB/TrEMBL
  TIR UniProtKB/TrEMBL
Superfamily-SCOP SSF52200 UniProtKB/TrEMBL
UniGene Cfa.48411 ENTREZGENE
UniProt A0A5F4BRV4_CANLF UniProtKB/TrEMBL
  A0A5F4CNR2_CANLF UniProtKB/TrEMBL
  E2RIV9 ENTREZGENE, UniProtKB/TrEMBL
  H6BA88_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:51831 ENTREZGENE