LRP5 (LDL receptor related protein 5) - Chinchilla Research Resource Database
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Gene: LRP5 (LDL receptor related protein 5) Canis lupus familiaris
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Symbol: LRP5
Name: LDL receptor related protein 5
CRRD ID: 12365689
Description: ENCODES a protein that exhibits coreceptor activity involved in Wnt signaling pathway (inferred); Wnt-activated receptor activity (inferred); Wnt-protein binding (inferred); INVOLVED IN bone development (ortholog); limb morphogenesis (ortholog); mammary gland duct morphogenesis (ortholog); PARTICIPATES IN altered Wnt signaling, canonical pathway; N-cadherin signaling pathway; Wnt signaling, canonical pathway; ASSOCIATED WITH Arteriovenous Fistula (ortholog); autosomal dominant osteopetrosis 1 (ortholog); autosomal dominant polycystic kidney disease (ortholog); FOUND IN integral component of membrane (inferred); plasma membrane (inferred); receptor complex (inferred)
Type: protein-coding
RefSeq Status: MODEL
Also known as: LOC106559978; low density lipoprotein receptor-related protein 5; LOW QUALITY PROTEIN: low-density lipoprotein receptor-related protein 5; low-density lipoprotein receptor-related protein 5; low-density lipoprotein receptor-related protein 5-like
Orthologs:
Homo sapiens (human) : LRP5 (LDL receptor related protein 5)  HGNC  Alliance
Mus musculus (house mouse) : Lrp5 (low density lipoprotein receptor-related protein 5)  MGI  Alliance
Rattus norvegicus (Norway rat) : Lrp5 (LDL receptor related protein 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lrp5 (LDL receptor related protein 5)
Pan paniscus (bonobo/pygmy chimpanzee) : LRP5 (LDL receptor related protein 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lrp5 (LDL receptor related protein 5)
Sus scrofa (pig) : LRP5 (LDL receptor related protein 5)
Chlorocebus sabaeus (African green monkey) : LRP5 (LDL receptor related protein 5)
Heterocephalus glaber (naked mole-rat) : Lrp5 (LDL receptor related protein 5)
more info ...
Latest Assembly: CanFam3.1 - Dog CanFam3.1 Assembly
Position:
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1849,439,483 - 49,516,396 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11849,439,494 - 49,555,375 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
adipose tissue development  (IBA)
anatomical structure regression  (IEA)
anterior/posterior pattern specification  (IBA)
apoptotic process involved in blood vessel morphogenesis  (IEA)
bone development  (ISO)
bone marrow development  (IBA)
bone morphogenesis  (IBA)
bone remodeling  (IBA)
branching involved in mammary gland duct morphogenesis  (IBA)
canonical Wnt signaling pathway  (IEA)
cell migration involved in gastrulation  (IEA)
cell-cell signaling involved in mammary gland development  (IEA)
cholesterol homeostasis  (IBA)
cholesterol metabolic process  (IEA)
embryonic digit morphogenesis  (IEA)
endocytosis  (IEA)
extracellular matrix-cell signaling  (IEA)
gastrulation with mouth forming second  (IBA)
glucose catabolic process  (IEA)
limb morphogenesis  (ISO)
mammary gland duct morphogenesis  (ISO)
negative regulation of osteoblast differentiation  (IEA)
negative regulation of protein serine/threonine kinase activity  (IEA)
Norrin signaling pathway  (IEA)
osteoblast development  (IBA)
positive regulation of cell population proliferation  (ISO)
positive regulation of DNA-binding transcription factor activity  (IEA)
positive regulation of fat cell differentiation  (IEA)
positive regulation of mesenchymal cell proliferation  (IEA)
positive regulation of mitotic nuclear division  (IEA)
positive regulation of osteoblast differentiation  (IEA)
positive regulation of osteoblast proliferation  (IEA)
positive regulation of skeletal muscle acetylcholine-gated channel clustering  (ISO)
positive regulation of transcription by RNA polymerase II  (IBA)
positive regulation of transcription, DNA-templated  (ISO)
regulation of apoptotic process  (IEA)
regulation of blood pressure  (IEA)
regulation of insulin secretion involved in cellular response to glucose stimulus  (IBA)
response to peptide hormone  (ISO)
response to radiation  (ISO)
retina morphogenesis in camera-type eye  (IEA)
retina vasculature morphogenesis in camera-type eye  (ISO)
retinal blood vessel morphogenesis  (IBA)
somatic stem cell population maintenance  (IEA)
vasculature development  (ISO)

Cellular Component

Molecular Pathway Annotations     Click to see Annotation Detail View
References

Genomics

Comparative Map Data
LRP5
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1 Ensembl1849,439,483 - 49,516,396 (-)EnsemblCanFam3.1canFam3CanFam3.1
CanFam3.11849,439,494 - 49,555,375 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
LRP5
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1168,312,591 - 68,449,275 (+)EnsemblGRCh38hg38GRCh38
GRCh381168,298,866 - 68,449,275 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371168,080,077 - 68,216,743 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361167,836,684 - 67,973,319 (+)NCBINCBI36hg18NCBI36
Build 341167,836,710 - 67,973,317NCBI
Celera1165,414,949 - 65,552,023 (+)NCBI
Cytogenetic Map11q13.2NCBI
HuRef1164,450,891 - 64,552,653 (+)NCBIHuRef
CHM1_11167,964,539 - 68,100,925 (+)NCBICHM1_1
Lrp5
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39193,634,825 - 3,736,574 (-)NCBI
GRCm38193,584,825 - 3,686,585 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl193,584,828 - 3,686,564 (-)EnsemblGRCm38mm10GRCm38
MGSCv37193,584,825 - 3,686,564 (-)NCBIGRCm37mm9NCBIm37
MGSCv36193,584,869 - 3,686,554 (-)NCBImm8
Celera193,456,985 - 3,596,074 (-)NCBICelera
Cytogenetic Map19ANCBI
Lrp5
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.01218,816,833 - 218,920,147 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1218,816,841 - 218,920,094 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01225,689,353 - 225,793,075 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41206,102,750 - 206,206,350 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.11206,256,235 - 206,359,808 (-)NCBI
Celera1198,369,819 - 198,473,093 (-)NCBICelera
Cytogenetic Map1q42-q43NCBI
Lrp5
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495542217,394,371 - 17,505,763 (-)EnsemblChiLan1.0
ChiLan1.0NW_00495542217,394,371 - 17,475,244 (-)NCBIChiLan1.0ChiLan1.0
LRP5
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11166,794,645 - 66,840,019 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1166,735,246 - 66,839,817 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01163,396,511 - 63,534,471 (+)NCBIMhudiblu_PPA_v0panPan3
Lrp5
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
SpeTri2.0NW_0049365991,746,309 - 1,814,471 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LRP5
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl24,533,593 - 4,653,945 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.124,533,721 - 4,653,997 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.223,168,598 - 3,216,170 (-)NCBISscrofa10.2Sscrofa10.2susScr3
LRP5
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1 Ensembl16,089,930 - 6,190,383 (-)Ensembl
ChlSab1.116,090,048 - 6,224,956 (-)NCBI
Lrp5
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_00462476718,438,165 - 18,551,362 (-)NCBI


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system reproductive system respiratory system adipose tissue
High
Medium 4 3 19 6 6 6 2 3 10 6
Low 1 2 3 4 6 9 4
Below cutoff 4

Sequence


Reference Sequences
RefSeq Acc Id: ENSCAFT00000017340   ⟹   ENSCAFP00000016050
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.1 Ensembl1849,439,483 - 49,516,396 (-)Ensembl
RefSeq Acc Id: XM_022405125   ⟹   XP_022260833
RefSeq Status:
Type: CODING
Position:
Dog AssemblyChrPosition (strand)Source
CanFam3.11849,439,494 - 49,555,375 (-)NCBI
Sequence:
Protein Sequences
Protein RefSeqs XP_022260833 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein ACT97161 (Get FASTA)   NCBI Sequence Viewer  
Reference Sequences
RefSeq Acc Id: XP_022260833   ⟸   XM_022405125
- Sequence:
RefSeq Acc Id: ENSCAFP00000016050   ⟸   ENSCAFT00000017340
Protein Domains
EGF-like


Additional Information

Database Acc Id Source(s)
Ensembl Genes ENSCAFG00000010871 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
Ensembl Protein ENSCAFP00000016050 ENTREZGENE, UniProtKB/TrEMBL
Ensembl Transcript ENSCAFT00000017340 ENTREZGENE, UniProtKB/TrEMBL
Gene3D-CATH 2.120.10.30 UniProtKB/TrEMBL
  4.10.400.10 UniProtKB/TrEMBL
InterPro 6-blade_b-propeller_TolB-like UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/TrEMBL
  LDL_receptor-like_sf UniProtKB/TrEMBL
  LDLR_class-A_CS UniProtKB/TrEMBL
  LDLR_classB_rpt UniProtKB/TrEMBL
  LDrepeatLR_classA_rpt UniProtKB/TrEMBL
  LRP5/6 UniProtKB/TrEMBL
NCBI Gene LRP5 ENTREZGENE
Pfam Ldl_recept_a UniProtKB/TrEMBL
  Ldl_recept_b UniProtKB/TrEMBL
PIRSF LDL_recpt-rel_p5/6 UniProtKB/TrEMBL
PRINTS LDLRECEPTOR UniProtKB/TrEMBL
PROSITE LDLRA_1 UniProtKB/TrEMBL
  LDLRA_2 UniProtKB/TrEMBL
  LDLRB UniProtKB/TrEMBL
SMART EGF UniProtKB/TrEMBL
  LDLa UniProtKB/TrEMBL
  SM00135 UniProtKB/TrEMBL
Superfamily-SCOP SSF57424 UniProtKB/TrEMBL
UniGene Cfa.44793 ENTREZGENE
UniProt C7FDX9_CANLF UniProtKB/TrEMBL
  F1PXA0_CANLF UniProtKB/TrEMBL
VGNC ID VGNC:49918 ENTREZGENE


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2017-11-21 LRP5  LDL receptor related protein 5  LOC106559978  low-density lipoprotein receptor-related protein 5-like  Data Merged 737654 PROVISIONAL