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Gene: TNFRSF1B (TNF receptor superfamily member 1B) Homo sapiens
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Symbol: TNFRSF1B
Name: TNF receptor superfamily member 1B
Description: Exhibits tumor necrosis factor binding activity and ubiquitin protein ligase binding activity. Involved in cellular response to lipopolysaccharide and positive regulation of membrane protein ectodomain proteolysis. Localizes to the membrane raft. Implicated in several diseases, including Legionnaires' disease; acne; bone disease (multiple); glomerulonephritis (multiple); and lung disease (multiple). Biomarker of several diseases, including acquired immunodeficiency syndrome; female reproductive organ cancer (multiple); glomerulonephritis (multiple); kidney failure (multiple); and lung disease (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD120b; p75; p75 TNF receptor; p75TNFR; p80 TNF-alpha receptor; soluble TNFR1B variant 1; TBPII; TNF-R-II; TNF-R2; TNF-R75; TNF-RII; TNFBR; TNFR-II; TNFR1B; TNFR2; TNFR80; tumor necrosis factor beta receptor; tumor necrosis factor binding protein 2; tumor necrosis factor receptor 2; tumor necrosis factor receptor superfamily member 1B; tumor necrosis factor receptor superfamily, member 1B; tumor necrosis factor receptor type II
Orthologs:
Mus musculus (house mouse) : Tnfrsf1b (tumor necrosis factor receptor superfamily, member 1b)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tnfrsf1b (TNF receptor superfamily member 1B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tnfrsf1b (TNF receptor superfamily member 1B)
Pan paniscus (bonobo/pygmy chimpanzee) : TNFRSF1B (TNF receptor superfamily member 1B)
Canis lupus familiaris (dog) : TNFRSF1B (TNF receptor superfamily member 1B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tnfrsf1b (TNF receptor superfamily member 1B)
Sus scrofa (pig) : TNFRSF1B (TNF receptor superfamily member 1B)
more info ...
Allele / Splice: See ClinVar data
Is Marker For: QTLs:   OSTEAR17_H   BP9_H  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38112,166,948 - 12,209,222 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37112,227,044 - 12,269,279 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36112,149,647 - 12,191,864 (+)NCBINCBI36hg18NCBI36
Build 34112,161,325 - 12,203,542NCBI
Celera111,340,352 - 11,382,470 (+)NCBI
Cytogenetic Map1p36.22NCBI
HuRef111,380,310 - 11,422,542 (+)NCBIHuRef
CHM1_1112,214,947 - 12,257,256 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on TNFRSF1B
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 1298224
Created: 2004-05-07
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.